Brief Article
Copyright ©2010 Baishideng.
World J Gastroenterol. Jan 21, 2010; 16(3): 379-383
Published online Jan 21, 2010. doi: 10.3748/wjg.v16.i3.379
Table 1 Demographic and viral characteristics and liver abnormalities of 634 subjects seropositive for hepatitis B surface antigen n (%)
VariablesGenotype B (n = 199)Genotype C (n = 411)Others (n = 24)1P value2
Age (yr)342.1 ± 13.041.3 ± 12.843.8 ± 12.80.493
Gender
Male116 (58.3)228 (55.5)16 (66.7)
Female83 (41.7)183 (44.5)8 (33.3)0.511
ALT (log10 U/L)31.4 ± 0.31.4 ± 0.31.4 ± 0.20.238
≤ 45 U/L174 (87.4)373 (90.8)23 (95.8)
> 45 U/L25 (12.6)38 (9.2)1 (4.2)0.207
HBeAg
Negative186 (93.5)385 (93.7)24 (100.0)
Positive13 (6.5)26 (6.3)00.922
HBV DNA levels (log10 copies/mL)33.7 ± 1.73.5 ± 1.73.1 ± 1.10.194
< 4151 (75.9)347 (84.4)23 (95.8)
≥ 448 (24.1)64 (15.6)1 (4.2)0.011
Fatty liver
Yes16 (8.0)24 (5.8)2 (8.3)
No183 (92.0)387 (94.2)22 (91.7)0.303
Cirrhosis status
Normal183 (92.0)350 (85.2)19 (79.2)
Probable cirrhosis416 (8.0)61 (14.8)5 (20.8)0.018
Table 2 Univariate and multivariate regression analyses for the risk factors of probable liver cirrhosis in the 595 HBeAg negative subjects infected with HBV
VariablesControls (n = 513)Cases (n = 82)OR (95% CI)AOR (95% CI)
Age (yr)
< 45284 (55.4)31 (37.8)
≥ 45229 (44.6)51 (62.2)2.04 (1.26-3.29)1.81 (1.10-2.99)
Sex
Female235 (45.8)25 (30.5)
Male278 (54.2)57 (69.5)1.93 (1.17-3.18)1.74 (1.03-2.95)
ALT (U/L)
≤ 45473 (92.2)66 (80.5)
> 4540 (7.8)16 (12.9)2.87 (1.52-5.41)2.98 (1.48-5.99)
Viral load (Log10 copies/mL)
< 4432 (84.2)67 (81.7)
≥ 481 (15.8)15 (18.3)1.19 (0.65-2.19)1.06 (0.54-2.08)
Genotype
B170 (34.4)16 (20.8)
C324 (65.6)61 (79.2)2.00 (1.12-3.58)2.30 (1.26-4.19)