Immunogenetic characteristics of patients with autoimmune gastritis

Table 1 Clinical characteristics of the 12 AIG patients

Patient	Sex	Age (yr)	Years from diagnosis	Other autoimmune diseases	AIG in family
1	F	50	7		-
2	F	56	3	RA	+
3	F	49	2		+
4	M	62	19		+
5	F	63	2	HT	+
6	F	54	3		-
7	F	38	4		+
8	F	56	5	PBC	-
9	F	52	0		-
10	F	52	0		-
11	F	47	15	T1D	-
12	F	52	0		-

AIG: Autoimmune gastritis; RA: Rheumatoid arthritis; HT: Hyperthyreosis; PBC: Primary biliary cirrhosis; T1D: Type 1 diabetes.

Table 2 HLA-A, B, Cw, DRB1 and DQB1 genotypes of the 12 AIG patients

Patient	HLA-A		HLA-B		HLA-Cw		HLA-DRB1		HLA-DQB1
1	03	11	07	44	01	07	12	15	0301	0602
2	02	-	15	51	04	14	04	08	0302	0402
3	02	24	15	39	04	07	04	15	0302	0602
4	02	03	07	18	07	-	04	15	0302	0602
5	02	26	15	40	03	04	01	08	0402	0501
6	02	03	15	-	03	-	04	08	0302	0402
7	02	-	13	51	06	15	07	09	0202	0303
8	02	32	40	51	02	15	09	15	0303	0602
9	03	-	07	51	03	15	04	13	0301	0303
10	02	03	35	40	04	07	04	12	0301	0302
11	02	-	27	35	01	03	03	08	0201	0402
12	03	24	13	35	04	06	04	-	0302	-

Table 3 IL-1, IL-10, and TNFα polymorphisms in 12 AIG patients, and in Finnish, Italian and Czech populations

	Genotype	AIG patients	Finnish[11] %	Italian[12] %	Czech[13] %
TNFα-308	AA1	-	3	2	2
	GA	-	21	14	38
	GG	12	76	84	60
IL-1β-511	TT1	-		9	10
	CT	8		41	45
	CC	4		50	45
IL1RA mspa111100	CC1	1		3	8
	TC	8		41	45
	TT	3		56	47
IL-10	ATA/ATA1	1		5
	ATA/ACC	1		21
	ACC/ACC	1		7
	GCC/ATA	5		24
	GCC/ACC	4		31
	GCC/GCC	-		12

¹The genotypes are the most proinflammatory ones.