Enhancement of antitumor vaccine in ablated hepatocellular carcinoma by high-intensity focused ultrasound

doi:10.3748/wjg.v16.i28.3584

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Jul 28, 2010 (publication date) through Apr 24, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Jul 28, 2010; 16(28): 3584-3591
Published online Jul 28, 2010. doi: 10.3748/wjg.v16.i28.3584

Table 1 Cytotoxicity rate of splenic lymphocytes against H22 and H16 tumor cells in the vaccinated and high-intensity focused ultrasound-treated mice (mean ± SD)

	Cytotoxicity rate (%)
	H22 tumor cells	B16 tumor cells
Control group	15.9 ± 3.6	13.5 ± 2.3
Tumor vaccine group	30.7 ± 2.7^d	14.1 ± 1.9
HIFU vaccine group	37.5 ± 4.5^a^d	13.8 ± 2.2
HIFU therapy group	62.7 ± 6.5^d^f	18.1 ± 3.9

^aP < 0.05 vs the tumor vaccine group;

^dP < 0.001 vs the control group;

^fP < 0.001 vs the HIFU vaccine and tumor vaccine groups. HIFU: High-intensity focused ultrasound.

Table 2 Tumor volume of the vaccinated and high-intensity focused ultrasound-treated mice after a subsequent H22 tumor challenge (mean ± SD)

	Average tumor volume (mm³) after H22 tumor challenge
	2 wk	3 wk	4 wk
Control group	343.3 ± 129.5	829.3 ± 316.4	1953.0 ± 848.2
Tumor vaccine group	504.1 ± 173.7	733.4 ± 301.3	1760.2 ± 1075.1
HIFU vaccine group	279.7 ± 117.2	382.8 ± 170.6^a^d	914.3 ± 474.2^a^d
HIFU therapy group	0	0	0

^aP < 0.05 vs the tumor vaccine group;

^dP < 0.01 vs the control group. HIFU: High-intensity focused ultrasound.

Table 3 CD86, CD80 and MHC-II expression by bone marrow-derived dendritic cells after incubation with high-intensity focused ultrasound- and tumor-generated vaccines (mean ± SD, %)

	CD86	CD80	MHC-II
Control group	2.05 ± 1.40	4.81 ± 1.56	3.04 ± 0.60
Tumor vaccine group	11.70 ± 0.85^b	13.50 ± 0.14^b	13.75 ± 0.59^b
HIFU vaccine group	14.65 ± 0.49^b	16.05 ± 0.50^b	15.90 ± 0.28^b

^bP < 0.001 vs the control. HIFU: High-intensity focused ultrasound.

Table 4 Interleukin-12 and interferon-γ secretion by bone marrow-derived dendritic cells after incubation with high-intensity focused ultrasound- and tumor-generated vaccines (mean ± SD)

	IL-12 (pg/mL)	IFN-γ (pg/mL)
Control group	80.2 ± 4.6	58.0 ± 0.9
Tumor vaccine group	206.8 ± 5.3^b	207.0 ± 3.4^b
HIFU vaccine group	264.7 ± 2.0^b	247.8 ± 9.0^b

^bP < 0.001 vs the control group. HIFU: High-intensity focused ultrasound; IL-12: Interleukin-12; IFN-γ: Interferon-γ.

Citation: Zhang Y, Deng J, Feng J, Wu F. Enhancement of antitumor vaccine in ablated hepatocellular carcinoma by high-intensity focused ultrasound. World J Gastroenterol 2010; 16(28): 3584-3591
URL: https://www.wjgnet.com/1007-9327/full/v16/i28/3584.htm
DOI: https://dx.doi.org/10.3748/wjg.v16.i28.3584