Long-term efficacy of perioperative chemoradiotherapy on esophageal squamous cell carcinoma

Table 1 Characteristics of the preoperative patients (n = 238)

	Pre-CRT (n = 80)	Post-CRT (n = 78)	S (n = 80)	Statistics
				χ2	P
Sex (M:F)	52:28	48:30	50:30	3.1326	0.209
Age (yr)				1.2375	0.975
40-	12	13	11
50-	24	25	24
60-	28	29	30
70-	16	11	15
Location				0.1920	0.996
Upper	11	10	12
Middle	45	45	44
Lower	24	23	24
CT staging				0.1165	0.943
II	35	33	36
III	45	45	44

Pre-CRT: Preoperative chemoradiotherapy; Post-CRT: Postoperative CRT; S: Surgery alone; CT: Computed tomography.

Table 2 Postoperative pathologic staging, perioperative complications, and cause of death n (%)

	Pre-CRT (n = 80)	Post-CRT (n = 78)	S (n = 80)	n = 238	Statistics
					χ2	P
Resection					-	0.0111
R	76 (97.4)	61 (78.2)	64 (80)	201 (84.5)
P	4 (2.6)	13 (16.7)	13 (16.3)	30 (12.6)
EB	0 (0)	4 (5.1)	3 (3.8)	7 (2.9)
Stage					-	0.0001
I	4 (2.6)	0 (0)	0 (0)	4 (1.7)
IIa	22 (27.5)	13 (16.7)	12 (15.4)	47 (19.7)
IIb	29 (36.3)	17 (21.8)	19 (23.8)	65 (27.3)
III	25 (31.3)	48 (61.5)	49 (61.3)	122 (51.3)
Complications					-	0.1791
Hemorrhage during
Surgery (> 300 mL)	8 (10.0)	2 (2.6)	2 (2.5)	12 (5.0)
Stomal leakage	1 (1.3)	0 (0)	0 (0)	1 (0.4)
Stomal stricture	2 (2.5)	3 (3.8)	1 (1.3)	6 (2.5)
Reflux esophagitis	13 (16.3)	13 (16.7)	15 (18.8)	41 (17.2)
Acute lung injury	3 (3.8)	0 (0)	0 (0)	3 (1.3)
Death					-	0.0111
Local recurrence	9 (11.3)	11 (14.1)	28 (35)	48 (20.2)
Distant metastasis	20 (25)	23 (29.5)	31 (38.8)	74 (31.1)
Treatment related	3 (3.8)	0 (0)	0 (0)	3 (1.3)
Not related	1 (1.3)	5 (6.4)	1 (1.3)	7 (2.9)

¹Fisher’s Exact test. R: Radical resection; P: Palliative resection; EB: Esophageal bypass.