Brief Articles
Copyright ©2009 The WJG Press and Baishideng.
World J Gastroenterol. Mar 7, 2009; 15(9): 1093-1098
Published online Mar 7, 2009. doi: 10.3748/wjg.15.1093
Table 1 Presence of metabolic risk factors and liver histology (steatosis/necroinflammation) in NASH cases
NASH patients (n = 69)
Fatty infiltration
Necroinflammation
Mild (%)Moderate (%)Severe (%)Mild (%)Moderate(%)Severe (%)
Gender
Male37.140.022.931.462.95.7
Female41.235.323.520.664.714.7
Hepatomegaly
(+)131.337.531.225.062.512.5
(-)138.538.523.027.061.511.5
Body mass index
18.5-24.9066.633.433.433.333.3
25-29.935.341.223.526.564.78.8
30-39.946.525.028.528.657.114.3
> 4025.075.0025.075.00
Central obesity
(+)38.840.820.426.563.310.2
(-)35.030.035.030.055.015.0
Hypertension
(+)33.433.333.319.062.019.0
(-)39.639.20.833.358.38.4
Diabetes
(+)40.035.025.033.457.19.5
(-)38.738.722.630.759.110.2
Hypertriglyceridemia
(+)36.234.029.821.463.814.8
(-)41.054.54.541.054.54.5
Insulin resistance
(+)33.336.730.013.373.413.3
(-)43.534.721.847.843.58.7
Table 2 Presence of metabolic risk factors and liver histology (stage) in NASH cases
NASH patients (n = 70)1
Fibrosis
Cirrhosis (%)
Absent (%)Perisinusoidal/Pericellular (%)Periportal (%)Bridging (%)
Gender
Male51.423.014.38.602.70
Female38.247.05.98.90-
Hepatomegaly
(+)244.131.26.312.55.90
(-)244.336.513.57.70-
Body mass index
18.5-24.933.3033.333.3-
25-29.938.244.111.75.8-
30-39.946.425.014.210.73.12
> 4025.075.000-
Central obesity
(+)46.930.616.36.12.04
(-)65.020.010.05-
Hypertension
(+)47.842.84.74.7-
(-)58.424.412.74.52.04
Diabetes
(+)28.538.014.214.24.76
(-)53.125.512.78.5-
Hypertrigly-ceridemia
(+)50.025.015.69.3-
(-)59.331.26.23.14.34
Insulin resistance
(+)53.336.613.33.33.33
(-)65.718.410.52.6-
Table 3 Dual combinations of risk factors and liver histology in NASH cases
Liver histologyNASH cases
Ob + DM (n = 6)Ob + Htg (n = 8)DM + Htg (n = 2)
Grade
1320
2261
3101
Stage
0130
1441
2100
3011
4000
Table 4 Liver histology according to the presence of metabolic syndrome in NASH cases (%)
Liver histologyPatients with NASH (n = 69)
With metabolic syndrome (n = 46, 66.6%)Without metabolicsyndrome (n = 23, 33.4%)
Fatty infiltration
Mild20 (43.4)11 (47.8)
Moderate19 (41.3)6 (26.1)
Severe7 (15.3)6 (26.1)
Necroinflammation
Absent0 (0)0 (0)
Mild13 (28.3)9 (39.1)
Moderate28 (60.9)13 (56.5)
Severe5 (10.8)1 (4.40)
Fibrosis
Absent20 (43.4)9 (39.1)
Perisinusoidal/pericellular16 (34.7)9 (39.1)
Periportal7 (15.4)2 (8.60)
Bridging3 (6.50)3 (13.2)
Cirrhosis1 (2.12)0 (0)