Meng W, Cai SR, Zhou L, Dong Q, Zheng S, Zhang SZ. Performance value of high risk factors in colorectal cancer screening in China. World J Gastroenterol 2009; 15(48): 6111-6116 [PMID: 20027686 DOI: 10.3748/wjg.15.6111]
Corresponding Author of This Article
Su-Zhan Zhang, Professor, Cancer Institute, The Second Affiliated Hospital, Zhejiang University School of Medicine, 88 Jiefang Road, Hangzhou 310009, Zhejiang Province, China. zhangsuzhan@yahoo.com
Article-Type of This Article
Brief Article
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Table 2 Colonoscopy results of high risk questionnaire items
Cancer
Advanced adenomas
Adenomas
Non-adenomatous polyps
Normal results
iFOBT
17
27
56
11
128
History of malignant tumor
1
3
9
7
41
Colorectal cancer (CRC) in first degree relatives
2
7
29
11
81
History of adenomatous polyps (HAP)
0
9
25
6
48
History of mucous and bloody stool
5
4
15
10
101
History of chronic diarrhea
2
10
29
10
120
History of chronic constipation
0
8
24
13
102
History of chronic appendicitis or appendectomy
3
9
33
14
122
History of chronic cholecystitis or cholecystectomy
3
14
50
19
169
History of psychiatric trauma
4
5
18
2
73
Table 3 Characteristics of the study population n (%)
Subjects with 2 analyzable tests (n = 13 214)
Sex
Male
5391 (40.8)
Female
7823 (59.2)
Age (yr)
40-49
2711 (20.5)
50-59
4704 (35.6)
60-69
3683 (27.9)
70-74
2116 (16.0)
Positive items
iFOBT
481 (3.6)
History of malignant tumor
172 (1.3)
CRC in first degree relatives
367 (2.8)
HAP
158 (1.2)
History of mucous and bloody stool
430 (3.3)
History of chronic diarrhea
709 (5.4)
History of chronic constipation
902 (6.8)
History of chronic appendicitis or appendectomy
1126 (8.5)
History of chronic cholecystitis or cholecystectomy
1538 (11.6)
History of psychiatric trauma
655 (5)
Table 4 Comparison of the performance of high risk factors in screening advanced neoplasias, adenomas, non-adenomatous polyps using HAP as reference
Advanced neoplasias
Adenomas
Non-adenomatous polyps
PPV (%)
NPV (%)
RSN
FP:TP
PPV (%)
NPV (%)
RSN
FP:TP
PPV (%)
NPV (%)
RSN
FP:TP
iFOBT
17.70
95.70
4.9 (2.42-9.87)
2.29 (1.36-3.83)
22.50
85.10
2.24 (1.4-3.52)
2.58 (1.37-4.87)
4.40
93
1.8 (0.71-4.58)
16 (3.39-75.58)
HMT
6.10
91.70
0.4 (0.17-1.19)
13.60
82.60
0.36 (0.18-0.7)
10.60
94
1.17 (0.39-3.48)
FDR
5.70
91.30
1 (0.4-2.519)
18.50
83.20
1.16 (0.69-1.96)
8.25 (0.44-154.47)
7
93.90
1.8 (0.67-4.88)
6.6 (1.16-37.6)
HAP
9.40
92
1
26
84
1
6.30
93.70
1
MBS
5.70
91.30
1 (0.42-2.39)
9.50
81.20
0.6 (0.33-1.08)
6.30
93.70
1.7 (0.66-4.38)
13.25 (2.02-86.77)
HCD
5.40
91
1.2 (0.54-2.63)
24 (1.87-307.35)
13.90
82
1.16 (0.72-1.88)
18 (1.1-293.1)
4.90
93.30
1.7 (0.71-4.08)
18 (3.2-101.33)
HCC
4.80
91
0.9 (0.35-2.33)
14.30
82.20
0.96 (0.56-1.65)
7.70
94.10
2.2 (0.88-5.49)
7.7 (2.26-26.21)
CAA
5.50
91
1.3 (0.59-2.83)
24.6 (1.63-370.18)
15.10
82.20
1.32 (0.8-2.16)
9.25 (1.52-55.7)
6.40
93.80
2.3 (0.88-5.99)
9.25 (2.96-28.79)
CCC
5.80
87.40
1.9 (0.87-4.12)
15.13 (4.47-51.23)
16.90
82.80
2 (1.26-3.16)
4.84 (2.43-9.65)
6.40
93.80
3.2 (1.38-7.42)
9.3 (4.5-19.22)
HPT
7.60
91.80
1 (0.42-2.39)
15.30
82.60
0.72 (0.43-1.2)
1.70
93
0.33 (0.07-1.63)
Citation: Meng W, Cai SR, Zhou L, Dong Q, Zheng S, Zhang SZ. Performance value of high risk factors in colorectal cancer screening in China. World J Gastroenterol 2009; 15(48): 6111-6116