Crosstalk between angiogenesis, cytokeratin-18, and insulin resistance in the progression of non-alcoholic steatohepatitis

Table 1 Characteristic features of patients with FL and NASH (mean ± SD)

	NASH (n = 28)	FL (n = 11)	P-value
Age (yr)	45.4 ± 14.7	43.6 ± 14.1	0.587
Sex (M/F)	17/11	7/4	0.660
BMI (kg/m2)	28.5 ± 6.91	25.8 ± 1.16	0.042
Total cholesterol (mg/dL)	218.6 ± 43.3	203.4 ± 48.3	0.350
Triglycerides (mg/dL)	186.1 ± 69.3	237.1 ± 98.2	0.075
FFA (mmol/L)	0.532 ± 0.207	0.897 ± 0.804	0.079
Fasting plasma glucose (mg/dL)	113.3 ± 30.0	98.8 ± 19.2	0.116
Fasting plasma insulin (μU/mL)	20.8 ± 11.5	10.0 ± 3.91	0.018
HOMA-IR	5.79 ± 4.15	2.26 ± 0.96	0.038
HbA1c (%)	6.09 ± 1.29	5.25 ± 0.53	0.130
Serum albumin (g/dL)	4.57 ± 0.33	4.54 ± 0.39	0.774
AST (IU/L)	63.4 ± 27.0	37.5 ± 10.0	0.012
ALT (IU/L)	105.5 ± 65.7	69.8 ± 31.2	0.035
γ-GTP (IU/L)	68.4 ± 37.1	64.2 ± 47.8	0.770
ZTT (kU)	7.87 ± 4.60	5.89 ± 2.39	0.224
Total bilirubin (mg/dL)	0.80 ± 0.25	1.00 ± 0.98	0.305
ICG R15 (%)	10.9 ± 4.28	9.00 ± 2.61	0.264
Procollagen-III-peptide (U/mL)	0.83 ± 0.31	0.96 ± 0.23	0.454
Collagen IV-7S (ng/mL)	4.46 ± 1.83	4.40 ± 1.52	0.762
Hyaluronic acid (ng/mL)	60.4 ± 57.6	15.0 ± 9.06	0.036
Platelets (104/μL )	21.2 ± 8.83	23.2 ± 4.85	0.470
Leptin (ng/mL)	7.23 ± 3.98	2.58 ± 0.43	0.040
Adiponectin (ng/mL)	5.06 ± 1.90	8.25 ± 0.95	0.016

FL: Fatty liver; NASH: Non-alcoholic steatohepatitis; M: Male; F: Female.