Significance and relationship between Yes-associated protein and survivin expression in gastric carcinoma and precancerous lesions

Table 1 Correlation of Yes-associated protein (YAP) expression with normal gastric mucosa, intestinal metaplasia (IM), dysplasia (DYS) and gastric carcinoma (GC)

Groups	n	YAP expression				Positive (%)	P
		-	+	++	+++
Normal mucosa	98	85	10	2	1	13.3	0.110a/0.009b
IM	58	42	12	3	1	27.6	0.625c/0.083d
DYS	32	20	9	3	0	37.5	0.653e
GC	98	51	30	12	5	48.0	0.0001f

Fisher’s exact test.

^aNormal mucosa vs IM;

^bNormal mucosa vs DYS;

^cIM vs DYS;

^dIM vs GC;

^eDYS vs GC;

^fNormal mucosa vs GC.

Table 2 Correlation of YAP expression with clinicopathologic features of gastric carcinoma

Groups	n	YAP expression				Positive (%)		P
		-	+	++	+++
Sex								0.309
Male	66	31	22	8	5	53.0
Female	32	20	8	4	0	37.5
Age								0.304
< 60	54	30	15	8	1	45.5
≥ 60	44	21	15	4	4	51.2
Gross type
EGC								0.937
Type I + IIc	18	6	8	3	1	66.7
Type III	10	4	3	2	1	60.0
AGC								0.074
Type BorI + II	7	2	2	2	1	71.4
Type BorIII + IV	62	38	17	5	2	38.7
WHO’s histological types							rk = 0.181	0.079
Well-diff. ade.	12	8	4	0	0	33.3		0.635a
Moderately-diff. ade.	25	14	6	3	2	44.0		0.673b
Poorly-diff. ade.	41	17	15	6	3	58.5		0.406c
Undiff. ade.	2	2	0	0	0	0.0
Papillary ade.	2	0	1	1	0	100.0
Signet ring cell carcinoma	7	4	2	1	0	42.9
Mucinous ade.	9	6	2	1	0	33.3
Lauren types								0.669
Intestinal type carcinoma	39	23	11	4	1	41.0
Diffused type carcinoma	59	28	19	8	4	52.5
Lymph node metastasis								0.602
Yes	52	28	16	5	3	46.2
No	17	12	3	2	0	29.4

Fisher’s exact test. ade.: Adenocarcinomas; diff.: Differentiated; EGC: Early gastric carcinoma; AGC: Advanced gastric carcinoma.

^aWell-diff. vs Moderately-diff. ade.;

^bModerately-diff. vs Poorly-diff. ade.;

^cWell-diff. vs Poorly-diff. ade..

Table 3 Correlation of survivin expression with normal gastric mucosa, intestinal metaplasia, dysplasia and gastric carcinoma

Groups	n	Survivin expression				Positive (%)	χ²	P
		-	+	++	+++
Normal mucosa	98	87	10	1	0	11.2		0.00011a/0.00011b
IM	58	27	19	8	4	53.4	2.683	0.4861c/0.443d
DYS	32	13	8	6	5	59.4	1.584	0.663e
GC	98	34	34	20	10	65.3	67.944	0.0001f

¹Fisher’s exact test.

^aNormal mucosa vs IM;

^bNormal mucosa vs DYS;

^cIM vs DYS;

^dIM vs GC;

^eDYS vs GC;

^fNormal mucosa vs GC.

Table 4 Correlation of survivin expression with clinicopathologic features of gastric carcinoma

Groups	n	Survivin expression				Positive (%)	χ²	P
		-	+	++	+++
Sex							4.87	0.172
Male	66	20	27	14	5	69.7
Female	32	14	7	6	5	56.2
Age							2.74	0.434
< 60	54	20	15	13	6	63.0
≥ 60	44	14	19	7	4	68.2
Gross type
EGC								0.3101
Type I + IIc	18	5	7	3	3	72.2
Type III	10	6	1	2	1	40.0
AGC								0.6961
Type BorI+ II	7	3	2	1	1	57.1
Type BorIII+ IV	62	19	24	14	5	69.4
WHO’s histological types							rk = 0.279	0.006
Well-diff. ade.	12	7	4	1	0	41.7		0.8241a
Moderately-diff. ade.	25	11	10	2	2	56.0		0.2231b
Poorly-diff. ade.	41	10	16	10	5	75.6		0.1491c
Undiff. ade.	2	1	1	0	0	50.0
Papillary ade.	2	1	0	1	0	50.0
Signet ring cell carcinoma	7	1	2	3	1	85.7
Mucinous ade.	9	3	1	3	2	66.7
Lauren types							8.61	0.035
Intestinal type carcinoma	39	19	14	4	2	51.3
Diffused type carcinoma	59	15	20	16	8	74.6
Lymph node metastasis								0.0051
Yes	52	12	19	15	6	76.9
No	17	10	7	0	0	41.2

¹Fisher’s exact test.

^aWell-diff. vs Moderately-diff. ade.;

^bModerately-diff. vs Poorly-diff. ade.;

^cWell-diff. vs Poorly-diff. ade..