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Copyright ©2009 The WJG Press and Baishideng.
World J Gastroenterol. May 28, 2009; 15(20): 2456-2462
Published online May 28, 2009. doi: 10.3748/wjg.15.2456
Table 1 HLA associations in IBD and IBD-associated arthropathy[11]
HLA antigens investigatedPercentage in IBD + arthropathy affected patientsPercentage in IBD patients without arthropathy
ASHLA-B*27607
TypeIarthritisHLA-B*27267
HLA-B*353315
HLA-DRB1*0103353
Type II arthritisHLA-B*446231
Table 2 Candidates genes and loci in CD and UC
Genes and lociAssociated with CDAssociated with UC
1p31IL23RYesYes
1q21ECM1-Yes
2q37ATG16L1YesNo
3p21Several included MST1-BSNYesYes
5p13Intergenic, PTGR4YesNo
5q31Several included SLC22A5YesYes
5q33IRGMYesNo
5q33IL12BYesYes
6q21HLA-DQ/DRYesYes
10q21ZNF365YesYes
10q24NKX2-3YesYes
16q12NOD2YesNo
17q21Several included STAT3YesYes
18p11PTPN2YesYes