Melatonin ameliorates experimental hepatic fibrosis induced by carbon tetrachloride in rats

doi:10.3748/wjg.15.1452

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Mar 28, 2009 (publication date) through Apr 26, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Mar 28, 2009; 15(12): 1452-1458
Published online Mar 28, 2009. doi: 10.3748/wjg.15.1452

Table 1 Pathologic grading of hepatic fibrosis in different groups

Group	Dose (mg/kg)	n	Pathologic grading of hepatic fibrosis					u value
	Dose (mg/kg)		0	I	II	III	IV
Normal	-	11	11	0	0	0	0	5.5681^b
Model	-	13	0	0	1	6	6	-
NAC	100	12	0	2	5	3	2	1.8838
MEL	2.5	11	0	2	4	2	3	1.5568
	5	13	0	2	4	3	4	1.3662
	10	12	0	4	4	1	3	2.1720^a

u represents the Ridit value of the two groups, P < 0.05 indicates u > 1.96; P < 0.01 indicates u > 2.58;

^aP < 0.05,

^bP < 0.01 vs model group.

Table 2 Effect of melatonin on serum ALT, AST levels and A/G value in different groups (mean ± SD)

Group	Dose (mg/kg)	n	ALT (U/L)	AST (U/L)	A/G
Normal	-	11	70.00 ± 35.27	139.82 ± 72.83	0.94 ± 0.40
Model	-	13	286.23 ± 121.91^b	431.00 ± 166.35^b	0.74 ± 0.09
NAC	100	12	194.42 ± 90.83^b^c	293.33 ± 94.60^b^c	0.78 ± 0.11
MEL	2.5	11	211.09 ± 97.03^b	357.09 ± 153.26^b	0.68 ± 0.15
	5	13	201.15 ± 101.16^b^c	321.23 ± 162.48^b^c	0.77 ± 0.15
	10	12	178.67 ± 103.14^b^d	292.42 ± 126.23^b^c	0.73 ± 0.07

ALT: Alanine aminotransferase; AST: Aspartate aminotransferase; A: Albumin; G: Globumin.

^bP < 0.01 vs normal control group;

^cP < 0.05 vs model control group;

^dP < 0.01 vs model control group.

Table 3 MDA content and GPx activity in liver homogenates of different groups (mean ± SD)

Group	Dose (mg/kg)	n	MDA (noml/mg prot)	GPx (U/mg prot)
Normal	-	11	4.3 ± 1.87	80.68 ± 10.76
Model	-	13	7.89 ± 1.49^b	49.13 ± 8.72^b
NAC	100	12	6.29 ± 1.36^b^c	64.68 ± 8.22^b^d
MEL	2.5	11	6.84 ± 1.10^b	53.44 ± 9.35^b
	5	13	6.29 ± 1.42^b^c	57.38 ± 7.65^b^c
	10	12	6.25 ± 2.27^b^c	61.39 ± 13.15^b^d

MDA: Malondialdehyde; GPx: Glutathione peroxidase.

^bP < 0.01 vs normal control group;

^cP < 0.05 vs model control group;

^dP < 0.01 vs model control group.

Table 4 Serum HA, LN and PIIINP levels in different groups (mean ± SD)

Group	Dose (mg/kg)	n	HA (&mgr;g/L)	LN (&mgr;g/L)	PIIINP (&mgr;g/L)
Normal	-	11	71.65 ± 27.64	37.65 ± 6.09	26.41 ± 7.28
Model	-	13	201.10 ± 68.46^b	55.26 ± 12.30^b	35.88 ± 5.92^b
NAC	100	12	131.31 ± 58.58^a^c	48.28 ± 4.93^b	32.89 ± 3.90^b
MEL	2.5	11	174.41 ± 72.99^b	48.15 ± 6.40^b	34.21 ± 5.76^b
	5	13	153.54 ± 86.19^b	48.22 ± 9.51^b	33.12 ± 4.71^b
	10	12	135.71 ± 76.03^a^c	45.89 ± 11.71^a^c	31.99 ± 6.09^a

HA: Hyaluronic acid; LN: Laminin; PIIINP: Procollagen III N-terminal peptide.

^aP < 0.05 vs normal control group;

^bP < 0.01 vs normal control group;

^cP < 0.05 vs model control group.

Citation: Hong RT, Xu JM, Mei Q. Melatonin ameliorates experimental hepatic fibrosis induced by carbon tetrachloride in rats. World J Gastroenterol 2009; 15(12): 1452-1458
URL: https://www.wjgnet.com/1007-9327/full/v15/i12/1452.htm
DOI: https://dx.doi.org/10.3748/wjg.15.1452