Is transient elastography a useful tool for screening liver disease?

Table 1 Liver stiffness in the normal population and factors influencing its measurement

	Corpechot C[11]	Roulot D[10]	Colombo S[12]
Number of subjects	71	429	327
Population	Healthy volunteers	Medical check-up	Blood donors
Mean stiffness (KPa)	4.8 (2.5-6.9)1	5.4 ± 1.52	4.9 ± 1.72
95th centile	-	8.6	7.8
Age	No effect	No effect	No effect
Gender	M > F	M > F	M = F
High BMI	Increased	Increased	Increased
Metabolic syndrome	-	Increased3	-
Fatty liver	-	-	Increased3

¹Range;

²Standard deviation;

³At multivariate analysis.

Table 2 Diagnostic performance of TE in the diagnosis of significant fibrosis

	Oliveri[14]	Marcellin[13]	Castera[35]	Ziol[15]	Fraquelli[3]	Corpechot[18]	Kelleher[16]	Yoneda[17]
Patients	268	170	183	251	200	95	129	67
F2 or higher (%)	69	50	74	65	50	60	50	49
Etiology	HBV	HBV	HCV	HCV	80% HCV	PBC/PSC	Nafld	Nafld
Cut Off (KPa)	7.5	7.2	7.1	8.8	7.9	7.3	8.7	6.6
Sensitivity (%)	93	70	67	56	72	84	81	82
Specificity (%)	88	83	89	91	84	87	78	81
AUROC	0.96	0.81	0.83	0.79	0.86	0.92	0.86	0.87

Table 3 Diagnostic performance of TE in the diagnosis of cirrhosis

	Olivieri[14]	Marcellin[13]	Castera[35]	Ziol[15]	Fraquelli[3]	Ganne-Carrié[5]	Corpechot[11]	Foucher[33]	Nguyen[36]	Yoneda[17]
Patients	268	202	183	251	200	775	95	354	103	67
Cirrhotics (%)	24	8	25	19	26	15	16	13	32	7.50
Etiology	HBV	HBV	HCV	HCV	80% HCV	All	PBC/PSC	All	Alcohol	Nafld
Cut-off (KPa)	11.8	11	12.5	14.6	11.9	14.6	17.3	17.6	19.5	17
Sensitivity (%)	86	93	87	86	91	79	93	77	91	93
Specificity (%)	96	87	91	96	89	95	95	97	100	95
AUROC	0.97	0.93	0.95	0.97	0.91	0.95	0.96	0.96	0.92	0.99