Requirements for transfusion and postoperative outcomes in orthotopic liver transplantation: A meta-analysis on aprotinin

Table 1A Volumes of RBCs transfused intraoperatively in the 4 studies

Study	Aprotinin group			Control group			yi (95% CI)
	Mean	SD	n	Mean	SD	n
	(units)	(units)		(units)	(units)
1 Garcia HL	13.0	8.0	39	14.4	9.7	41	-1.4 (-5.29, 2.49)
2 Marcel RJ	2.1	2.0	21	3.0	4.4	23	-0.9 (-2.89, 1.09)
3 Dalmau A1	2.44	3.03	63	2.14	2.32	64	0.3 (-0.64, 1.24)
4 Llamas P	8.1	5.2	20	13	7.4	30	-4.9 (-8.39, -1.41)

¹Control group used tranexamic acid.

Table 1B Weighted mean differences (WMDs) in the volumes of RBCs transfused intraoperatively

	Heterogeneity		WMD	Z test		95% CI
	Q	P	(units)	Z	P
A	8.87	0.03	-1.23	1.24	0.21	-3.17 to 0.71
B	3.85	0.15	-1.80	2.23	0.03	-3.38 to -0.22

A: Total results; B: Results with study No. 3 excluded.

Table 2A Volumes of FFP transfused intraoperatively in the 4 studies

Study	Aprotinin group			Control group			yi (95% CI)
	Mean	SD	n	Mean	SD	n
	(units)	(units)		(units)	(units)
1 Garcia HL	26.0	16.0	39	28.0	15.0	41	-2.00 (-8.80, 4.80)
2 Marcel RJ	3.6	3.5	21	6.6	6.1	23	-3.00 (-5.91, -0.09)
3 Dalmau A1	1.09	2.20	63	1.20	2.21	64	-0.11 (-0.88, 0.66)
4 Llamas P	16.7	10.4	20	28	14	30	-11.3 (-18.07, -4.53)

¹Control group used tranexamic acid.

Table 2B Weighted mean differences (WMDs) in the volumes of FFP transfused intraoperatively

	Heterogeneity		WMD	Z test		95% CI
	Q	P	(units)	Z	P
A	13.77	0.003	-3.13	1.68	0.09	-6.79 to 0.53
B	5.25	0.07	-3.99	3.14	0.002	-6.47 to -1.50

A: Total results; B: Results with study No. 3 excluded.

Table 3A Postoperative outcomes of the 5 studies

Study	Aprotinin group				Control group				ORi1, 95% CI	ORi2, 95% CI	ORi3, 95% CI
	n	n1	n2	n3	n	n1	n2	n3
1 James Y	33	0	1	1	30	1	4	2	0.29 (0.01, 7.48)	0.20 (0.02, 1.93)	0.44 (0.04, 5.09)
2 Garcia HL	39	1	2		41	1	3		1.05 (0.06, 17.43)	0.68 (0.11, 4.34)
3 Porte RJ	89	5	7	2	48	5	2	3	0.51 (0.14, 1.87)	1.96 (0.39, 9.85)	0.34 (0.06, 2.14)
4 Dalmau A1	63	1	2	2	64	4	2	4	0.24 (0.03, 2.23)	1.02 (0.14, 7.45)	0.49 (0.09, 2.79)
5 Llamas P	20	4	0		50	6	7		1.83 (0.46, 7.35)	0.14 (0.01, 2.60)

n1: Number of deaths; n2: Number of laparotomy for bleeding; n3: Number of thromboembolic events;

¹Control group used tranexamic acid.

Table 3B Odds ratios of the postoperative outcomes

		Heterogeneity of ORi		OR	χ2 test		95% CI
		Q	P		χ2	P
Death	A	3.32	0.51	0.69	0.48	> 0.05	0.32-1.52
	B	2.21	0.53	0.85	0.06	> 0.05	0.36-2.00
Laparotomy for bleeding	A	4.09	0.39	0.65	0.44	> 0.05	0.29-1.43
	B	3.94	0.27	0.59	0.57	> 0.05	0.25-1.41
Thrombotic events	A	0.08	0.96	0.42	2.33	> 0.05	0.14-1.30
	B	0.02	0.88	0.38	1.75	> 0.05	0.09-1.64

A: Total results; B: Results with study No. 4 excluded.