Gastric motor effects of ghrelin and growth hormone releasing peptide 6 in diabetic mice with gastroparesis

Table 1 Effects of GHS-R agonists on the spontaneous contractile amplitudes of DM mouse fundic strips

Group	Spontaneous contractile amplitude of DM mouse fundic strips (mg)
	0	0.01&mgr;mol/L	0.1&mgr;mol/L	1&mgr;mol/L	10&mgr;mol/L
Ghrelin	20.4 ± 1.15	21.3 ± 0.98	19.8 ± 1.16	22.1 ± 1.58	21.5 ± 1.36
GHRP-6	20.4 ± 1.15	20.8 ± 1.12	21.3 ± 1.74	20.6 ± 1.27	21.3 ± 1.35

Table 2 Effect of GHS-R agonists on the carbachol (0.1 &mgr;mol/L)-induced contractile amplitudes of DM mouse fundic strips

Group	Spontaneous contractile amplitude of DM mouse fundic strips (mg)
	0	0.01&mgr;mol/L	0.1&mgr;molL	1&mgr;mol/L	10&mgr;mol/L
Ghrelin + carbachol (0.1 &mgr;mol/L)	60.4 ± 1.21	61.3 ± 1.52	65.7 ± 1.16a	70.0 ± 1.58a	78.0 ± 1.56a
GHRP-6 + carbachol (0.1 &mgr;mol/L)	60.4 ± 1.21	62.3 ± 2.14	65.4 ± 1.24a	72.0 ± 1.42a	82.0 ± 1.75a

^aP < 0.05, vs carbachol (0.1 &mgr;mol/L)-induced contraction amplitude of the DM mouse fundic strips.