Absence of Na+/sugar cotransport activity in Barrett’s metaplasia

Table 1 Uptake of AMG by duodenal, gastric fundic, and esophageal mucosal biopsies (mean ± SE)

	pmoles AMG mg wet wt	pmoles AMG/&mgr;g DNA
Duodenum	711.53 ± 121.63 (11)	249.84 ± 35.49 (12)
Fundus	41.04 ± 2.35 (12)b	36.20 ± 6.62 (12)b
Esophagus	45.52 ± 3.76 (3)a	12.10 ± 0.59 (3)d
Barrett’s	50.27 ± 4.32 (9)b	29.79 ± 5.77 (8)b

The number in parenthesis represents the biopsies tested. Three biopsies were taken from each tissue site of each patient.

^bP < 0.001 vs duodenum;

^aP < 0.02 vs duodenum;

^dP < 0.01 vs duodenum (Student's t-test). There was no significant difference (P > 0.05) between Barrett’s esophagus biopsies and biopsies of fundus or normal esophagus.

Table 2 Inhibition of AMG uptake by 0.5 mmol/L phlorizin in duodenal, gastric fundic, and esophageal mucosal biopsies (mean ± SE)

	Control	Phlorizin
Duodenum	593.34 ± 120.23 (7)	65.05 ± 14.41 (7)b
Fundus	35.00 ± 1.82 (8)	30.27 ± 4.23 (8)a
Esophagus	36.73 ± 4.85 (8)	27.20 ± 2.63 (8)a
Barrett’s	53.09 ± 5.57 (6)	42.66 ± 4.37 (7)a

The number in parenthesis represents the biopsies tested.

^bP < 0.001 vs matched control (Student's t-test);

^aP > 0.05 vs control.

Table 3 Sodium dependence or independence of AMG uptake by duodenal, gastric fundic, and esophageal mucosal biopsies (mean ± SE)

	Lithium	Sodium
Duodenum	49.31 ± 5.86 (10)b	544.85 ± 110.20 (10)d
Fundus	35.20 ± 2.73 (8)	41.15 ± 1.91 (7)
Esophagus	44.83 ± 4.03 (9)	41.56 ± 5.07 (9)
Barrett’s	40.47 ± 1.47 (5)	48.03 ± 11.72 (5)

The number in parentheses represents the biopsies tested.

^bP < 0.001,

^dP < 0.001 vs all other samples. There was no significant difference between lithium and sodium samples.