Transjugular intrahepatic portosystemic shunt-placement increases arginine/asymmetric dimethylarginine ratio in cirrhotic patients

Table 1 Demographic data and parameters of hepatic andrenal function

	Demographic data
Number of patients	25
Gender: Male/Female	18/7
Age: Median (range)	55 (40-81)
TIPS indication
Ascites	20
Esophageal varices	2
Others	3
Child-Pugh classification
A	5
B	14
C	6
Biochemical markers of hepatic function	Median	IQR	Reference range
Bilirubin (mmol/L)	20	13-35	< 17
Aspartate aminotransferase (U/L)	19	13-34	< 50
Alanine aminotransferase (U/L)	15	7-27	< 50
Alkaline phosphatase (U/L)	135	99-185	< 124
Prothrombin time (%)	72	59-81	> 70
Factor V (%)	52	40-80	> 75
Antithrombin (%)	67	48-79	> 75
Fibrinogen (mg/dL)	299	232-408	180-350
Albumin (g/L)	35	31-41	37-53
Cholinesterase (U/L)	2049	1461-2800	5320-12 920
Alpha-fetoprotein (ng/mL)	3.1	2.5-4.0	< 8.1
Biochemical markers of renal function
Urea (mmol/L)	13	8-18	4-18
Creatinine (μmol/L)	77	59-113	< 97
Creatinine clearance (mL/min)	80	38-115	97-160

Table 2 Biochemical markers of renal function

	Just before TIPS		Directly after TIPS		3 mo after TIPS
	Median	IQR	Median	IQR	Median	IQR
Urea (mmol/L)	13	8-18	12	5-33	11a	5-16
Creatinine (μmol/L)	77	59-113	63	54-107	70a	57-89
Creatinine clearance (mL/min)	80	38-115	110	75-138	128a	97-161

^aP < 0.05 vs just before TIPS-placement.

Table 3 Pressure (mmHg) in portal vein and right atrium

	Just before TIPS		Directly after TIPS		3 mo after TIPS
	Median	IQR	Median	IQR	Median	IQR
Portal vein	30	20-35	23a	16-27	17a	10-23
Right atrium	9	1-12	13a	5-17	6a	2-15
Gradient (pv-ra)	21	19-24	10a	9-11	11a	7-15

Pv: Portal vein; ra: Right atrium.

^aP < 0.05 vs just before TIPS-placement.

Table 4 Plasma concentrations (μmol/L) of ADMA, SDMA, and arginine

	Just before TIPS		Directly after TIPS		3 mo after TIPS
	Median	IQR	Median	IQR	Median	IQR
ADMA
Caval vein	0.64	0.58-0.72	0.69	0.61-0.78	0.59	0.53-0.74
Portal vein	0.67	0.60-0.79	0.7	0.62-0.80	0.58	0.52-0.77
Hepatic vein	0.62	0.59-0.71	0.66	0.57-0.84	0.57	0.52-0.74
SDMA
Caval vein	0.74	0.60-1.16	0.81	0.64-1.11	0.61a	0.46-0.86
Portal vein	0.79	0.62-1.13	0.72	0.64-1.06	0.62a	0.46-0.89
Hepatic vein	0.79	0.61-1.09	0.77	0.64-1.09	0.60a	0.44-0.89
Arginine
Caval vein	64	56-85	76	68-102	77a	65-104
Portal vein	69	62-93	79	64-102	90a	70-106
Hepatic vein	54	46-75	67	59-88	72a	57-101
Arginine/ADMA
Caval vein	95	83-132	117	89-141	128a	110-175
Portal vein	83	68-123	98	80-130	123a	92-152
Hepatic vein	108	88-138	114	88-137	141a	112-185

^aP < 0.05 vs just before TIPS-placement.

Table 5 Plasma concentrations of NO_x (μmol/L)

NOx	Just before TIPS		Directly after TIPS		3 mo after TIPS
	Median	IQR	Median	IQR	Median	IQR
Systemic vein	112	37-243	107	33-212	44	26-103
Portal vein	83	35-241	85	45-223	57	21-96
Hepatic vein	85	35-304	86	32-220	39	21-76