Role of chemokines and their receptors in viral persistence and liver damage during chronic hepatitis C virus infection

Table 1 Chemokines and their receptors

	Chemokine receptor	Chemokine ligands	Target cells
Subfamily CC
	CCR1	CCL3, CCL5, CCL7, CCL14	T cells, monocytes, basophils and eosinophils
	CCR2	CCL2, CCL8, CC7, CCL13, CCL16	Memory T cells, monocytes and dendritic cells
	CCR3	CCL11, CCL13, CCL7, CCL5, CCL8, CCL13	Eosinophils, basophils, mast cells, T helper 2 cells and platelets
	CCR4	CCL17, CCL22	T helper 2 cells, dendritic cells, basophils, macrophages and platelets
	CCR5	CCL3, CCL4, CCL5, CCL11, CCL14, CCL16	T cells, monocytes
	CCR6	CCL20	T cells, B cells and dendritic cells
	CCR7	CCL19, CCL21	T cells and dendritic cells
	CCR9	CCL25	T cells, plasma cells
	CCR10	CCL27, CCL28	T cells
Subfamily CXC
	CXCR1	CXCL8, CXCL6	Neutrophils and monocytes
	CXCR2	CXCL8, CXCL1, CXCL2, CXCL3, CXCL5, CXCL6	Neutrophils, monocytes and vascular endothelial cells
	CXCR3-A	CXCL9, CXCL10, CXCL11	T helper 1 cells, mast cells and mesangial cells
	CXCR3-B	CXCL4, CXCL9, CXCL10, CXCL11	Neoplastic cells and vascular endothelial cells
	CXCR4	CXCL12	Expressed in multiple cells
	CXCR5	CXCL13	B cells and T helper cells
	CXCR6	CXCL16	CD8+ cells, natural killer cells and memory CD4+ cells
Subfamily CX3C
	CX3CR1	CX3CL1	Macrophages and smooth muscle cells
Subfamily XC
	XCR1	XCL1, XCL2	T cells and natural killer cells