Effects of fluoxetine on mast cell morphology and protease-1 expression in gastric antrum in a rat model of depression

Table 1 Average immunofluorescence intensity analysis of rMCP-1 alterations in gastric antrum of depressed rat model (n = 10, mean ± SE)

Group	Fluorescence intensity of MCP-1
Normal control	24.8 ± 5.6
Fluoxetine + control	23.1 ± 3.4b
Depressed	37.4 ± 7.7d
Saline + depressed	39.9 ± 5.0d
Fluoxetine + depressed	26.1 ± 3.6b

rMCP-1: rat mast cell protease- 1.

^bP < 0.01 vs depressed model control group;

^dP < 0.01 vs normal control group.

Table 2 Ultrastructural morphologic changes of gastric tissue mast cells (n = 10, mean ± SE)

Group	Mast cells/30 visual fields	Normal mast cells (%)	Activated mast cells (%)
Normal control	24.0 ± 3.5	64.6 ± 9. 9	35.4 ± 3.7
Fluoxetine + control	22.2 ± 3.4c	69.8 ± 6.1c	30.2 ± 3.7c
Depressed	40.6 ± 3.9b	33.3 ± 4.7b	66.7 ± 4.9b
Saline + depressed	42.2 ± 3.7b	30.4 ± 3.7b	69.6 ± 4.7b
Fluoxetine + depressed	28.1 ± 3.3ad	44.4 ± 5.6ad	55.6 ± 5.6ad

^aP < 0.05,

^bP < 0.01 vs normal control group;

^cP < 0.05,

^dP < 0.01 vs depressed model control group.