Cholangiocarcinoma: A compact review of the literature

Table 1 Memorial Sloan Kettering T stage for hilar CC

Stage	Criteria
T1	Tumor involving biliary confluence ± unilateral extension to second-order biliary radicals
T2	T1 ± ipsilateral portal vein involvement ± ipsilateral hepatic lobar atrophy
T3	Tumor involving biliary confluence + bilateral extension to second-order biliary radicals; or unilateral extension to second-order biliary radicals with contralateral portal vein involvement; or unilateral extension to second-order radicals with contralateral hepatic lobar atrophy; or main or bilateral portal vein involvement

Table 2 Summary of some studies indicating potential influence of liver resection on tumor margin-negative resections and 5-year survival data on hilar CC (1986-1999)

	Resection	Liver resection	Operativemortality	Margin- (%)	5-yr survival
					Margin-	Margin+
Kosuge et al 1999[55]	65	80	9	52	56	13
Burke et al 1998[56]	30	73	6	83	40	0
Miyazaka et al 1998[57]	76	86	13	71	26	0
Nagino et al 1998[58]	138	90	9	76	21	-
Klempnauer et al 1996[59]	151	78	10	76	31	5
Nimura et al 1986[60]	100	91	10	55	35	0

Table 3 Summary of some recent studies indicating 1-, 3- and 5-yr survival data on margin-negative tumor resections of hilar CC (2000-2005)

	Resections	1-yr survival	3-yr survival	5-yr survival
		(margin-)	(margin-)	(margin-)
Jarnagin et al 2005[65]	25	100	80	45
	81	85	45	30
Silva et al 2005[64]	19	83	58	41
Kondo et al 2004[63]		-	-	40
Neuhaus et al 2003[62]	133	70	42	36
Tsao et al 2000[66]	25	-	-	43