Liver Cancer
Copyright ©2008 The WJG Press and Baishideng.
World J Gastroenterol. Oct 14, 2008; 14(38): 5816-5822
Published online Oct 14, 2008. doi: 10.3748/wjg.14.5816
Table 1 Metastasis-related proteins in HCC
Protein nameIPI numberRatio1NO2Coverage (%)3Category
Filamin CIPI001783522.49 ± 0.1521.28Cytoskeleton
ObscurinIPI005498222.91 ± 0.1821.16Cytoskeleton
Keratin 8IPI005546480.56 ± 0.15425.1Cytoskeleton
TitinIPI001793571.73 ± 0.1251.11Cytoskeleton
Plectin 7IPI003987762.49 ± 0.1321.19Cytoskeleton
MTA2IPI001717980.24 ± 0.1122.69p53 regulation
Low density lipoprotein receptor-related protein 1 (LRP1)IPI000205570.58 ± 0.1522.27Cell migration, proliferation, angiogenesis
MosIPI000182902.86 ± 0.226.36Mitoses
Table 2 KEGG pathway analysis of metastasis-related proteins
KEGG pathwayIPI accessionProtein description
Antigen processing and presentationIPI00020984Calnexin precusor
IPI00025252Protein disulfide-isomerase A3 precusor
IPI00037070Splice isoform 2 of heat shock cognate 71 kDa protein
IPI00144014MHC Cass I antigen
IPI00514377Heat shock 70 kDa protein
Regulation of actin cytoskeletonIPI00001814Serine/threonine- protein kinase PAK 7
IPI00018290Mos
IPI00216691Profiline-1
IPI00384231PAK4 protein
Renal cell carcinomaIPI00001814PAK 7
IPI00384231PAK4 protein
Thyroid cancerIPI00022970Translocated promoter region
Small cell lung cancerIPI00217461Splice isoform 3 of apoptotic protease activating factor 1
IPI00377045Laminin alpha 3 splice variant B1
Prostate cancerIPI00219757Glutahione S-transferase protein
p53 pathwayIPI00006160Splice isoform alpha of tumor protein P73
IPI00217461Splice isoform 3 of apoptotic protease activating factor 1
MAPK pathwayIPI00018290Mos
IPI00037070Splice isoform 2 of heat shock cognate 71 kDa protein (HSP70)
IPI00155892Voltage-dependent calcium channel gamma-5 subunit isoform B
IPI00178352Splice isoform 1 of filamin C
IPI00382696Splice isoform 1 of filamin B
IPI00514377Heat shock 70 kDa protein 1A
ErbB pathwayIPI00001814PAK 7
IPI00384231PAK4
Table 3 Function classification of protein-protein interaction network
Cell functionInteractorsPercent (%)
Cell cycle60.69
DNA repair576.54
Stress response141.61
Protein biosynthesis91.03
Carbohydrate metabolism262.99
DNA replication30.34
Transcription394.48
RNA processing141.61
RNA localization10.11
Signal transduction12013.78
Transport414.71
Protein dephosphorylation91.03
Cell organization and biogenesis12414.24
Metabolism708.04
DNA damage response30.34
Protein transport596.77
Protein phosphorylation606.89
Protein degradation374.25
DNA repair131.49
Unknown16619.06