Abaza MSI, Bahman AMA, Al-Attiyah RJ. Roscovitine synergizes with conventional chemo-therapeutic drugs to induce efficient apoptosis of human colorectal cancer cells. World J Gastroenterol 2008; 14(33): 5162-5175 [PMID: 18777593 DOI: 10.3748/wjg.14.5162]
Corresponding Author of This Article
Dr. Mohamed-Salah I Abaza, Molecular Biology Program, Department of Biological Sciences, Faculty of Science, Kuwait University, PO Box 5696, Safaat 13006, Kuwait. abaza@kuc01.kuniv.edu.kw
Article-Type of This Article
Colorectal Cancer
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Table 8 Analysis of the combined effects of vinblastine and Rosco on human colorectal cancer cell lines
Combined treatment of vinblastine and Rosco
Combination interaction at various durations of treatment in human colorectal cancer cells1
SW48
SW1116
SW837
2 d
4 d
6 d
2 d
4 d
6 d
2 d
4 d
6 d
Vinb 1.0 IC50 + Rosco 10 μg/mL
ant
ant
ant
add
add
add
ant
syn
syn
Vinb 2.0 IC50 + Rosco 15 μg/mL
ant
syn
ant
syn
ant
ant
ant
ant
ant
Vinb 3.0 IC50 + Rosco 20 μg/mL
ant
ant
ant
syn
ant
ant
ant
ant
ant
Vinb 4.0 IC50 + Rosco 25 μg/mL
ant
ant
ant
syn
ant
ant
ant
ant
ant
Citation: Abaza MSI, Bahman AMA, Al-Attiyah RJ. Roscovitine synergizes with conventional chemo-therapeutic drugs to induce efficient apoptosis of human colorectal cancer cells. World J Gastroenterol 2008; 14(33): 5162-5175