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Copyright ©2008 The WJG Press and Baishideng.
World J Gastroenterol. Sep 7, 2008; 14(33): 5138-5148
Published online Sep 7, 2008. doi: 10.3748/wjg.14.5138
Table 1 Anatomic compartments of GALT
Gut segment
Inductive/effector sitesStructureAbbreviationSmall intestine
Large intestine3
EffectorLamina propriaLP+++++++++
Intraepithelial lymphocytesIEL+++++++++
InductivePeyer’s patchPP++++-
Intestinal lymph follicleiLF++++-
Intestinal lymph aggregateiLA+++++
Mesenteric lymph nodeMLN---
Table 2 Mucosal DCs and their proposed function
Intestinal compartment2
cDCCD4-CD8-+++++++++++++++Express CD103 or CX3CR1.12-14, 47, 86, 99
CD11b+CD11c+Mediate intestinal antigen acquisition.
Involved in the RA dependent Treg conversation.
Permitting homing of conventional T cells to intestinal tissues by inducing CCR9 and α4β7.
CD4+CD8-CD11b+CD11c++++--+++Prime CD4 T cell responses.8, 28
CD4-CD8+CD11b-CD11c+++--++++Prime CD8 T cell responses.8, 28
pDCB220+PDCA1+CD11c+++/-+/-++Produce type I interferons10