Calcium signaling and T-type calcium channels in cancer cell cycling

Table 1 Cancerous cells that expresses T-type Ca²⁺ channels

Cell type	Cell line	T-type isoform	Reference
Breast carcinoma	MCF-7, MDA-435	α1G,α1H	[33-36]
	MDA-231, MDA-361 MB-468, MB-474, BT-20, CAMA1, SKBR-3	α1G	[34-36]
Neuroblastoma	SK-N-SH,	α1G	[34,37-40]
	NG 108-15, SK-N-MC
	N1E-115	α1G,α1H	[37]
Retinoblastoma	Y-79, WERI-Rb1	α1G,α1H,α1I	[41,42]
Glioma	Primary (biopsy)	α1G	[36]
	U87-MG	α1G,α1H	[37]
Prostate carcinoma	TSU-PRL, DUPRO	α1G	[35,43]
	LNCaP	α1H	[1,34,35]
	PC-3, DU-145	α1G,α1H	[34,35]
Esophageal carcinoma	TE1, TE10, TE12, KYSE150, KYSE180, KYSE450	α1H	[44]
	SKGT4, TE3, TE7, KYSE70	α1G,α1H	[44]
	COLO-680N, SEG1, TE8, TE11, KYSE30, KYSE410, KYSE510	α1G,α1H,α1I	[44]
Fibrosarcoma	HT1080	α1G	[45]
Colorectal carcinoma	Caco2, DLD-1, Lovo, SW837	α1G	[35]
Pheochromocytoma	MPC 9/3L	α1G	[46]
	PC-12	α1H	[47]
Adenocarcinoma	H295R	α1H	[48]
Insulinoma	INS-1	α1G	[49]

Table 2 Q-RT-PCR detected T-type Ca²⁺ channels expression in non-confluent cultures of breast cancer cell lines

Cell types	T-channels	Non-confluentΔct	ConfluentΔct
MDA-MB-231	α1H	14.28 ± 0.16	NA, ct > 40
MDA-MB-231	α1G	9.45 ± 0.87	NA, ct > 40
MCF-7	α1H	13.43 ± 0.24	NA, ct > 40
MCF-7	α1G	7.32 ± 0.3	NA, ct > 40

NA: Not applicable.