Prevalence of metabolic syndrome, obesity and diabetes type 2 in cryptogenic cirrhosis

Table 1 Demographic, clinical and laboratory parameters of patients with cryptogenic cirrhosis and non-cryptogenic cirrhosis

Variable	Cryptogenic (n = 134, %)	Non-cryptogenic (n = 134, %)	P
Sex (female)	83 (62)	75 (56)	0.32
DM	53 (40)	30 (22.4)	0.013
HBP	24 (18)	14 (10.4)	0.08
Hyperuricemia	13 (10)	2 (1.5)	0.003
Dyslipidemia	72 (54)	8 (6)	< 0.001
Overweight (BMI > 25)	103 (77)	106 (79)	0.65
Obesity (BMI > 30)	22 (16.4)	11 (8.2)	0.04
MS	39 (29.1)	8 (6)	< 0.001
Age (yr, mean ± SD)	54.6 ± 14.3	56.8 ± 11.4	0.15
BMI (mean ± SD)	27 ± 4.6	26 ± 4	0.22
ALT (U/L, mean ± SD)	52.5 ± 59	57.5 ± 33	0.72
AST (U/L, mean ± SD)	67.1 ± 60	77.8 ± 46	0.19

DM: Diabetes mellitus; HBP: High blood pressure; BMI: Body mass index (calculated as patient’s body weight divided by the square of the height expressed in kg/m²); MS: Metabolic syndrome.

Table 2 Comparison of patients with cryptogenic cirrhosis with and without liver tissue examination

Variable	Liver biopsy (n = 56, %)	No liver biopsy (n = 78, %)	P
Sex (female)	37 (66)	46 (59)	0.47
DM	13 (23)	40 (51)	0.001
HBP	7 (13)	17 (22)	0.18
Hyperuricemia	3 (5)	10 (13)	0.03
Dyslipidemia	21 (38)	51 (65)	0.002
Overweight (BMI > 25)	46 (82)	57 (73)	0.29
Obesity (BMI > 30)	4 (7)	18 (23)	0.017
MS	10 (18)	29 (37)	0.02
Child-Pugh A	29 (52)	24 (31)	0.02
Age (yr, mean ± SD)	55.8 ± 14.5	53.7 ± 14	0.42
BMI (mean ± SD)	26.2 ± 4.6	27.3 ± 4.6	0.28
ALT (U/L, mean ± SD)	51.8 ± 38	52.9 ± 70	0.91
AST (U/L, mean ± SD)	66 ± 48	68 ± 69	0.86
Albumin (g/dL, mean ± SD)	3.3 ± 0.7	2.9 ± 0.6	0.01
Alkaline Phosphatase (U/L, mean ± SD)	150 ± 72	154 ± 74	0.7
Child-Pugh score (mean ± SD)	6.9 ± 2.7	7.7 ± 1.8	0.06

DM: Diabetes mellitus; HBP: High blood pressure; BMI: Body mass index (calculated as patient’s body weight divided by the square of the height expressed in kg/m²); MS: Metabolic syndrome.

Table 3 Comparison of patients with cryptogenic cirrhosis and disease controls separated by the etiology of cirrhosis

Variable	Cryptogenic (n =134, %)	CHC (n = 81, %)	Alcohol (n = 33, %)	AIH (n = 20, %)	P
Sex (female)	83 (62)	54 (66.7)	7 (21.2)	14 (70)	< 0.001
DM	53 (40)	17 (21)	10 (30.3)	3 (15)	0.013
HBP	24 (18)	8 (10)	4 (12.1)	2 (10)	0.36
Hyperuricemia	13 (10)	1 (1.2)	0 (0)	1 (5)	0.027
Dyslipidemia	72 (54)	5 (6)	1 (3)	2 (10)	< 0.001
Overweight (BMI > 25)	103 (77)	63 (78)	27 (81.8)	16 (80)	0.93
Obesity (BMI > 30)	22 (16.4)	5 (6.2)	5 (15.2)	1 (5)	0.10
MS	39 (29.1)	5 (6.2)	2 (6)	1 (5)	< 0.001
Age (yr, mean ± SD)	54.6 ± 14.3	56.8 ± 11.4	58 ± 12.6	55.6 ± 14.1	0.48
BMI (mean ± SD)	27 ± 4.6	26 ± 4	26.4 ± 3.5	26.1 ± 5.1	0.65
ALT (U/L, mean ± SD)	52.5 ± 59	57.5 ± 33	52.6 ± 47.9	46.2 ± 27.7	0.79
AST (U/L, mean ± SD)	67.1 ± 60	77.8 ± 46	73.1 ± 52	73.5 ± 69	0.59

CHC: Cirrhosis by hepatitis C virus; AIH: Autoimmune hepatitis; DM: Diabetes mellitus; HBP: High blood pressure; BMI: Body mass index (calculated as patients’ body weight divided by the square of the height expressed in kg/m²); MS: Metabolic syndrome.