Abrupt onset of type 1 diabetes mellitus during recombinant interferon-alpha 2b therapy in a patient with chronic hepatitis B

Table 1 Laboratory findings in the patient on admission

	Laboratory findings
Urinalysis
Glucose	(+++)
Ketobody	(++++)
Protein	(-)
CBC
RBC	3.94 × 1012/L
Hb	124 g/L
WBC	5.1 × 109/L
Plt	62 × 109/L
Blood chemistry
Fasting plasma glucose	31.7 mmol/L (570.6 mg/dL)
Arterial blood gas analysis
pH	7.314
PCO2	35.1 mmHg
PO2	70.6 mmHg
HCO3-	11.5 mmol/L
BE	-3.6 mmol/L
TP	87.1 g/L
ALB	48 g/L
AST	36 IU/L
ALT	40 IU/L
ALP	98 IU/L
GGT	21 IU/L
Serology
HbA1c	10.0%
HBs Ag	(+)
HBs Ab	(-)
HBe Ag	(-)
HBe Ab	(-)
HBcAb	(+)
HBV DNA (PCR)	< 1000 copies/mL
IgG	18.37 g/L
IgA	2.79 g/L
IgM	1.87 g/L
TSH	0.636 mIU/mL
FT3	4.03 pmol/L
FT4	16.3 pmol/L
TPOAb	(-)
TgAb	(-)
ANA	(-)
Anti-DNA Ab	(-)
RF	(-)

Table 2 Results of oral glucose tolerance test (75 g)

Time (min)	Blood glucose (mmol/L)	C-peptide (pmol/mL)
0	7.5	0.29
30	10.8	0.40
60	15.0	0.61
120	18.3	0.77
180	14.1	0.78