Development of hepatorenal syndrome in bile duct ligated rats

Table 1 Renal function parameters in sham-operated (Sham) and bile duct ligated rats at 2-wk, 4-wk and 6-wk (mean ± SD)

	Sham (n = 17)	2-wk (n = 8)	4-wk (n = 7)	6-wk (n = 7)
Urinary volume (mL/24 h)	12 ± 0.5	14.2 ± 1.0	19.4 ± 1.7a	20.4 ± 2.8a
Serum creatinine (mg/dL)	0.60 ± 0.10	0.28 ± 0.05a	1.21 ± 0.25a	2.50 ± 0.40a
Creatinine clearance (mL/min)	1.14 ± 0.19	1.31 ± 0.11	0.97 ± 0.43	0.47 ± 0.25a
Serum osmolality (mOsm/kg)	292 ± 2	289 ± 4	280 ± 14a	282 ± 3a
Urinary osmolality (mOsm/kg)	2147 ± 115	1578 ± 76a	1499 ± 117a	1745 ± 73a
Osmolal clearance (mL/min)	0.061 ± 0.003	0.049 ± 0.002	0.071 ± 0.009	0.088 ± 0.013
Free water clearance (mL/min)	-0.052 ± 0.003	-0.040 ± 0.002a	-0.056 ± 0.008	-0.074 ± 0.011a
Serum [Na+] (mEq/L)	137 ± 1	138 ± 3	125 ± 3a	126 ± 2a
Urinary [Na+] (mEq/L)	111 ± 13	102 ± 10	57 ± 15a	50 ± 15a
Na+ excreted (mEq)	1.47 ± 0.15	1.59 ± 0.19	1.20 ± 0.33	1.09 ± 0.34
Fractional Na+ excreted (%)	0.65 ± 0.17	0.63 ± 0.13	0.91 ± 0.40	1.72 ± 0.61
Serum [K+] (mEq/L)	4.5 ± 0.3	5.1 ± 0.4	4.0 ± 0.5	4.3 ± 0.1
Urinary [K+] (mEq/L)	281 ± 12	269 ± 5	199 ± 21a	180 ± 27a
K+ excreted (mEq)	3.35 ± 0.17	4.12 ± 0.31a	3.65 ± 0.56	3.38 ± 0.39
Fractional K+ excreted (%)	38 ± 6	43 ± 8	> 100a	> 100a

[Na⁺], sodium concentration; [K⁺], potassium concentration.

^aP < 0.05 vs sham group.