Esophageal Cancer
Copyright ©2008 The WJG Press and Baishideng.
World J Gastroenterol. Jul 7, 2008; 14(25): 3990-3996
Published online Jul 7, 2008. doi: 10.3748/wjg.14.3990
Table 1 Inhibition effect of Gecko-contained serum on EC9706 by MTT assay (mean ± SD, n = 6)
Groups24 h
48 h
72 h
AInhibition rate (%)AInhibition rate (%)AInhibition rate (%)
NS0.472 ± 0.050.97 ± 0.1181.63 ± 0.224
CTX0.286 ± 0.06a39.10.55 ± 0.09a420.82 ± 0.163a49.6
Gecko 10.355 ± 0.04a24.80.65 ± 0.136a32.50.99 ± 0.154a39.1
Gecko 20.372 ± 0.07a210.721 ± 0.09a25.11.15 ± 0.925a29.8
Gecko 30.393 ± 0.03a16.40.756 ± 0.07a22.41.27 ± 0.07a22.3
Table 2 Inhibition effect of Gecko-contained serum on EC1 by MTT assay (mean ± SD, n = 6)
Experiment24 h
48 h
72 h
AInhibition rate (%)AInhibition rate (%)AInhibition rate (%)
NS0.282 ± 0.090.506 ± 0.051.329 ± 0.73
CTX0.19 ± 0.03a32.60.298 ± 0.124a41.10.673 ± 0.08a48.7
Gecko 10.215 ± 0.08a24.80.368 ± 0.03a27.20.865 ± 0.08a34.1
Gecko 20.234 ± 0.04a16.60.378 ± 0.03a25.10.94 ± 0.112a30.5
Gecko 30.255 ± 0.05a9.50.426 ± 0.08a15.81.075 ± 0.132a18
Table 3 Inhibitory effects of Gecko on transplanted sarcoma 180 in mice (mean ± SD, n = 10)
GroupsDose (g/kg)Weight(g)
Tumor weight (g)Inhibitory rate (%)
Pre-treatmentPost-treatment
NS26.1 ± 2.5728.1 ± 2.642.167 ± 0.592
CTX0.126.2 ± 2.1324.3 ± 2.91a0.548 ± 0.135b74.6
Gecko 113.526.5 ± 2.4428.8 ± 3.011.087 ± 0.249b49.8
Gecko 29.026.1 ± 2.1126.6 ± 2.181.021 ± 0.288b52.8
Gecko 34.525.4 ± 1.9027.8 ± 3.741.234 ± 0.331b43.1
Table 4 Influence of Gecko on immune organs of transplanted sarcoma 180 in mice (mean ± SD, n = 10)
GroupsDose (g/kg)Thymus index (× 10-3)Spleen index (× 10-3)Phagocytic rate(%)Phagocytic index
NS2.662 ± 0.1318.143 ± 0.29430.20.414
CTX0.11.939 ± 0.981a5.376 ± 0.570a7.0b0.085b
Gecko 113.52.260 ± 0.0926.943 ± 0.30616.8a0.206a
Gecko 29.02.680 ± 0.0647.418 ± 0.20919.0a0.218a
Gecko 34.52.376 ± 0.0517.354 ± 0.23620.5a0.231a
Table 5 Expressions of VEGF, bFGF and AI on S180 tissues in mice (mean ± SD, n = 10)
GroupsDose (g/kg)AI (%)Immunoreactive score
VEGFbFGF
NS3.58 ± 0.875.80 ± 0.734.81 ± 0.82
CTX0.117.95 ± 2.14b4.00 ± 0.38a3.00 ± 0.63a
Gecko 113.511.28 ± 1.03b4.62 ± 0.52a3.34 ± 0.77a
Gecko 29.013.56 ± 2.13b4.75 ± 0.68a3.46 ± 0.56a
Gecko 34.511.05 ± 1.69b4.83 ± 0.72a3.52 ± 0.62a