Shen Z, Li YM, Yu CH, Shen Y, Xu L, Xu CF, Chen JJ, Ye H, Xu GY. Risk factors for alcohol-related liver injury in the island population of China: A population-based case-control study. World J Gastroenterol 2008; 14(14): 2255-2261 [PMID: 18407605 DOI: 10.3748/wjg.14.2255]
Corresponding Author of This Article
Professor You-Ming Li, Department of Gastroenterology, The First Affiliated Hospital, Medicine School, Zhejiang University, Hangzhou 310003, Zhejiang Province, China. zlym@zju.edu.cn
Article-Type of This Article
Rapid Communication
Open-Access Policy of This Article
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World J Gastroenterol. Apr 14, 2008; 14(14): 2255-2261 Published online Apr 14, 2008. doi: 10.3748/wjg.14.2255
Table 1 Relationship between variables and alcohol-related liver injury detected by using univariate logistic-regression
Variable
β
S.E.
Waldχ2
P
OR
95% CI
Male gender
1.152
0.228
25.448
0.000
3.163
2.022-4.948
Age
-0.008
0.007
1.162
0.281
0.992
0.978-1.006
Education level
0.061
0.127
0.229
0.632
1.063
0.829-1.362
Unmarried state
-0.144
0.408
0.125
0.724
0.866
0.389-1.926
Smoking
0.810
0.190
18.184
0.000
2.248
1.549-3.262
Daily alcohol intake ≥ 20 g
1.460
0.201
52.562
0.000
4.307
2.902-6.392
Duration of drinking ≥ 5 years
1.729
0.237
53.324
0.000
5.633
3.542-8.958
Total alcohol intake ≥ 36.5 kg
1.506
0.208
52.582
0.000
4.507
3.000-6.711
Hypertension
0.473
0.209
5.128
0.024
1.605
1.066-2.418
Obesity
0.671
0.188
12.673
0.000
1.956
1.352-2.829
Table 2 Multivariate logistic-regression analysis of alcohol-related liver injury and selected variables
Variable
β
S.E.
Waldχ2
P
OR
95% CI
Daily alcohol intake ≥ 20 g
0.676
0.286
5.584
0.018
1.965
1.122-3.442
Duration of drinking ≥ 5 years
1.227
0.329
13.884
0.000
3.412
1.789-6.507
Obesity
0.635
0.206
9.518
0.002
1.887
1.261-2.824
Table 3 Prevalence rate of alcohol-related liver injury (%)
Variable
Total ALI
ALI in obese
ALI in non-obese
Daily alcohol intake(g)
< 20
45/373
(12.06)
22/157
(14.01)
23/216
(10.65)
≥ 20
104/280
(37.14)
60/119
(50.42)
44/161
(27.33)
Duration of drinking (yr)
<5
25/293
(8.53)
12/118
(10.17)
13/175
(7.43)
≥ 5
124/360
(34.44)
70/158
(44.30)
54/202
(26.73)
Table 4 Relationship between different daily alcohol intake and BMI
Group
ALI
Normal
χ2
P
OR
95%CI
X0
23
193
-
-
-
-
X1
44
117
17.564
0.000
3.156
1.813-5.492
X2
22
135
0.970
0.325
1.367
0.732-2.553
X3
60
59
65.121
0.000
8.534
4.864-14.972
Y0
13
162
-
-
-
-
Y1
54
148
23.911
0.000
4.547
2.385-8.668
Y2
12
106
0.678
0.410
1.411
0.620-3.209
Y3
70
88
60.338
0.000
9.913
5.194-18.918
Table 5 Dose-response to daily alcohol intake, drinking time and alcohol-related liver injury
Characteristics
Total
ALI
χ2
P
OR (95%CI)
PR (%)
PR
Daily alcohol intake (g)
< 20
373
45
-
-
-
12.06
1.00
20-40
76
25
20.817
0.000
3.573 (2.019-6.324)
32.89
2.73
40-80
73
27
28.011
0.000
4.278 (2.424-7.552)
36.99
3.07
80-160
65
24
25.774
0.000
4.267 (2.360-7.715)
36.92
3.06
≥ 160
66
28
37.283
0.000
5.371 (3.010-9.584)
42.42
3.52
Duration of drinking (yr)
< 5
293
25
-
-
-
8.53
1.00
5-10
22
4
2.279
0.131
2.382 (0.748-7.587)
18.18
2.13
10-20
58
22
36.082
0.000
6.551 (3.351-12.806)
37.93
4.45
20-40
206
76
60.265
0.000
6.267 (3.808-10.313)
36.89
4.32
≥ 40
74
22
23.773
0.000
4.535 (2.379-8.647)
29.73
3.49
Table 6 Different types of alcoholic beverage and alcohol-related liver injury
Type of beverage
Total
ALI (n, %)
Daily intake (g)
χ2
P
Beer
126
38 (30.16)
40.26 ± 31.35
-
-
Yellow rice wine
36
14 (38.89)
78.15 ± 57.88
0.979
0.322
Hard liquor
41
16 (39.02)
107.09 ± 84.38
1.111
0.292
Multiple
110
44 (40.00)
167.26 ± 109.60
2.509
0.113
Total
313
112 (35.78)
Citation: Shen Z, Li YM, Yu CH, Shen Y, Xu L, Xu CF, Chen JJ, Ye H, Xu GY. Risk factors for alcohol-related liver injury in the island population of China: A population-based case-control study. World J Gastroenterol 2008; 14(14): 2255-2261