Effect of Prometheus liver assist system on systemic hemodynamics in patients with cirrhosis: A randomized controlled study

Table 1 Pre-treatment clinical status of patients with liver failure

No	Randomization	Sex	Age(yr)	Cause	MELDscore	Child-Pughscore	Comagrade	INR	Bilirubin(&mgr;mol/L)	Albumin(g/L)	Creatinine(&mgr;mol/L)	Hg(g/L)	Platelet count(× 104/L)	6-mooutcome
1	Hemodialysis	M	51	Alcoholic cirrhosis
2	Prometheus	M	66	Hemochromatosis	24	C/13	II	2.5	7.1	23.6	0.7	6.2	105	Died
3	Prometheus	M	60	Alcoholic cirrhosis	22	B/9	I	1.5	2.8	39.8	2.1	5.2	126	OLT/survived
4	MARS	M	59	Alcoholic cirrhosis	25	C/14	I	2.7	8.0	25.6	0.6	5.4	22	Died
5	MARS	F	44	Alcoholic cirrhosis	24	C/13	I	2.2	11.9	17.8	0.8	6.0	148	Survived
6	Hemodialysis	F	54	Alcoholic cirrhosis	32	C/14	I	2.7	41.0	19.3	0.7	6.5	66	Died
7	Hemodialysis	F	57	PBC
8	Prometheus	M	39	Porphyria	22	C/10	0	1.4	22.8	31.8	0.4	8.0	70	OLT/survived
9	Prometheus	F	25	Alcoholic cirrhosis	31	C/12	0	2.3	26.9	20.0	1.3	6.2	109	OLT/survived
10	Prometheus	F	59	Autoimmune hepatitis	35	C/12	I	1.8	15.6	34.0	3.3	6.2	71	Died
11	Prometheus	F	49	Alcoholic cirrhosis	25	C/12	I	2.4	9.6	29.2	0.7	7.1	63	Survived
12	MARS	F	43	Alcoholic cirrhosis	29	C/12	I	1.8	35.8	25.0	1.3	6.3	123	Survived
13	MARS	F	45	Cholest. stor. dis.	22	C/11	I	2.2	5.0	29.3	1.1	5.2	57	OLT/survived
14	MARS	M	59	Autoimmune hepatitis	26	C/10	0	1.7	35.1	31.3	0.9	8.8	31	Survived
15	MARS	M	63	Alcoholic cirrhosis	11	B/8	0	1.2	1.9	31.7	0.8	7.0	65	Survived
16	Hemodialysis	M	54	Hepatitis C	20	C/10	I	1.9	1.1	35.2	1.8	7.5	87	Survived
17	Hemodialysis	M	67	Alcoholic cirrhosis	12	B/9	I	1.4	1.6	30.4	0.7	6.6	91	OLT/survived
18	Hemodialysis	M	61	Alcoholic cirrhosis	12	B/8	I	1.2	1.2	35.1	1.4	8.3	140	Died
19	Prometheus	F	63	Unknown	10	B/8	I	1.3	1.1	40.8	0.8	8.0	146	Survived
20	Prometheus	M	57	Alcoholic cirrhosis	48	C/13	II	6.0	36.6	28.5	2.3	6.0	74	Died
21	MARS	M	65	Alcoholic cirrhosis	18	B/7	0	1.3	1.6	39.0	2.0	7.2	99	Survived
22	MARS	M	57	Hepatitis C	38	C/12	I	2.2	36.8	32.1	2.5	5.8	37	Died
23	Hemodialysis	M	59	Alcoholic cirrhosis	23	C/14	I	2.4	5.5	24.6	0.4	5.6	46	Died
24	Hemodialysis	M	52	Alcoholic cirrhosis	23	C/10	I	1.5	4.0	41.8	0.5	6.8	221	Survived

PBC: Primary biliary cirrhosis; Cholest. stor. dis: Cholesterol esther storage disease.

Table 2 Hemodynamic variables (mean ± SEM)

		Hemodialysis		MARS		Prometheus
Variables		Pre-treatment	Post-treatment	Pre-treatment	Post-treatment	Pre-treatment	Post-treatment
CO	L/min	8.26 ± 1.07	8.37 ± 1.01	8.66 ± 0.87	8.74 ± 0.88	9.52 ± 1.26	9.36 ± 1.4
HR	beats/min	74.5 ± 5.89	78.5 ± 8.45	79.5 ± 6.06	81.13 ± 6.53	82.25 ± 6.06	81.63 ± 6.88
MAP	mmHg	75.17 ± 6.99	76.5 ± 5.13	68.88 ± 3.82	78.13 ± 4.87	74 ± 3.52	74.38 ± 5
PAPM	mmHg	14.17 ± 2.98	12.83 ± 2.23	18.5 ± 2.25	19.88 ± 2.09	24.88 ± 5.71	23.25 ± 5.32
PAWP	mmHg	7.17 ± 1.56	5.83 ± 1.74	11.38 ± 1.61	13 ± 2.1	13.63 ± 2.24	14.63 ± 1.86
CVPM	mmHg	6.83 ± 2.8	3.83 ± 1.38	9.5 ± 2.15	8.63 ± 1.69	13.25 ± 1.81	12 ± 2.05
SV	mL	107.78 ± 11.86	112.18 ± 10.95	106.95 ± 8.78	107.56 ± 7.28	116.11 ± 13.54	110.91 ± 13.49
CI	L/min•m2	4.12 ± 0.5	4.26 ± 0.49	4.71 ± 0.56	4.71 ± 0.51	4.9 ± 0.56	4.9 ± 0.67
SVRI	DS*m2•cm5	1454.17 ± 478.92	1541.17 ± 353.82	1223.38 ± 344.76	1372.25 ± 271.5	1073.5 ± 126.69	1177.38 ± 194.2
PVRI	DS*m2•cm5	138.5 ± 32.22	119.67 ± 29.05	121.5 ± 30.65	100.05 ± 28.13	236 ± 141.71	210.63 ± 133.63

CO: Cardiac output; HR: Heart rate; MAP: Mean arterial blood pressure; PAPM: Pulmonary artery pressure mean; PAWP: Pulmonary artery wedged pressure; CVPM: Central venous pressure middle; SV: Stroke volume; CI: Cardiac index; SVRI: Systemic vascular resistance index; PVRI: Pulmonary vascular resistance index.