Rapid Communication
Copyright ©2008 The WJG Press and Baishideng.
World J Gastroenterol. Mar 21, 2008; 14(11): 1785-1789
Published online Mar 21, 2008. doi: 10.3748/wjg.14.1785
Table 1 Characteristics of cases and controls
Controls/casesOR 95% CI
Sex
Male101/701
Female98/670.986 (0.638-1.524)
Age (yr)
≤ 6098/601
> 60101/771.245 (0.804-1.928)
Smoking status
Non-smoker147/751
Smoker52/622.337 (1.473-3.708)b
Alcohol duration (yr)
Never168/1031
1-1516/141.427 (0.669-3.046)
> 1515/202.175 (1.066-4.437)
Body mass index (kg/m2)
18.5-22.9101/351
23-24.938/544.101 (2.329-7.220)
> 2560/482.309 (1.345-3.962)d
Table 2 COX-2 -765G>C genotypes and risk of CRC
Controls/casesOR1 95% CI
COX-2 genotype
GG169/1191
GC29/170.867 (0.461-1.632)
CC1/1
Table 3 Relationship between C-1562T and R279Q genotypes and clinicopathological features of CRC
-765G>C GG/GC+CCOR1 95% CI
Age (yr)
< 6049/111
≥ 6070/70.445 (0.161-1.230)
Sex
Male60/101
Female59/80.814 (0.300-2.204)
Lymph node metastasis
N(-) (n = 87)75/121
N(+)41/50.762 (0.251-2.314)
TNM classification
StageI22/41
> Stage II94/130.761 (0.226-2.558)
External membrane invasion
(+)91/111
(-)25/61.985 (0.668-5.898)
Table 4 COX-2 genotypes and risk for CRC in association with smoking status, alcohol duration and BMI
-765GG
-765GC+CC
Controls/casesOR (95% CI)Controls/casesOR (95% CI)
Smoking status
Never126/68121/71
Smoker43/512.682 (1.336-5.385)b9/117.963 (0.615-103.051)
Alcohol duration (yr)
Never143/89125/141
1-1513/120.750 (0.303-1.855)3/20.713 (0.044-11.599)
> 1513/180.810 (0.259-2.531)2/20.199 (0.005-7.669)
Body mass index (BMI)
18.5-22.986/31115/41
23-24.932/463.909 (2.081-7.344)6/85.128 (0.867-30.320)
> 2551/422.031 (1.107-3.726)d9/66.281 (0.864-45.631)