Gene expression profile of esophageal cancer in North East India by cDNA microarray analysis

Table 1 Demographic and clinical characteristics of esophageal squamous cell carcinoma cases

PatientID	Age	Sex	Tobacco/smoking habit	Alcoholuse	Betel nutchewing	Pathologicalgrade
EC-61	55	M	Yes	Yes	Yes	G2
EC-64	45	M	Yes	Yes	Yes	G1
EC-55	52	M	Yes	Yes	Yes	G1
EC-103	59	M	Yes	Yes	Yes	G2
EC-111	55	M	Yes	Yes	Yes	G3
EC-90	50	M	Yes	Yes	Yes	G1
EC-117	60	M	Yes	No	Yes	G3
EC-73	50	M	Yes	No	Yes	G3
EC-125	71	M	Yes	No	Yes	G2
EC-110	70	M	Yes	Yes	Yes	G2
EC-146	45	M	Yes	No	Yes	G2
EC-136	48	M	Yes	Yes	Yes	G2
EC-127	58	M	Yes	Yes	Yes	G1
EC-121	55	M	Yes	Yes	Yes	G2
EC-76	50	M	Yes	Yes	Yes	G2
EC-81	55	M	Yes	Yes	Yes	G1

G1 = Well differentiated squamous cell carcinoma; G2= Moderately differentiated squamous cell carcinoma; G3= Poorly differentiated squamous cell carcinoma.

Table 2 List of significantly upregulated genes in esophageal cancer patients

Category	Genesincategory	% Genesincategory	Genesin listin category	% Genesin listcategory	P-value
GO: 4930: G-protein coupled receptor activity	150	2.148	23	3.433	0.0156
GO: 8324: cation transporter activity	307	4.396	39	5.821	0.0404
GO: 4674: protein serine/threonine kinase activity	285	4.081	38	5.672	0.022
GO: 4707: MAP kinase activity	20	0.286	5	0.746	0.0368
GO: 4161: dime- thylallyltransferase activity	4	0.0573	3	0.448	0.00327

Table 3 List of significantly down-regulated genes in esophageal cancer patients

Category	Genesincategory	% Genesincategory	Genesin list incategory	% Genesin listcategory	P-value
GO: 3735: structural constituent of ribosome	115	1.647	32	4.992	5.54E-09
GO: 4869: cysteine protease inhibitor activity	27	0.387	11	1.716	1.19E-05
GO: 5200: structural constituent of cytoskeleton	63	0.902	12	1.872	0.011
GO: 16746: transferase activity, transferring acyl groups	90	1.289	19	2.964	0.000422
GO: 16209: antioxidant activity	25	0.358	9	1.404	0.000232
GO: 3746: translation elongation factor activity	14	0.2	5	0.78	0.00636