Molecularly defined adult-type hypolactasia among working age people with reference to milk consumption and gastrointestinal symptoms

doi:10.3748/wjg.v13.i8.1230

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Feb 28, 2007 (publication date) through Apr 25, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Clinical Research

World J Gastroenterol. Feb 28, 2007; 13(8): 1230-1235
Published online Feb 28, 2007. doi: 10.3748/wjg.v13.i8.1230

Table 1 Frequency of the C/T_-13910 genotypes

Genotype	% (n)	GI-complaints % (n)	P
C/C_-13910	18 (341)	24 (84)	< 0.05
C/T_-13910	47 (901)	43 (148)	NS
T/T_-13910	35 (658)	33 (116)	NS
Total	100 (1900)	100 (348)

Table 2 The frequency of gastrointestinal symptoms according to the three genotype groups of lactase persistence/nonpersistence during previous three months

Abdominal complaints	C/C % (n)	C/T % (n)	T/T % (n)	OR C/C vs C/T	P	OR C/C vs T/T	P
				(95% CI)		(95% CI)
During previous three months	84 (280/332)	79 (698/885)	78 (501/641)	1.44 (1.03-2.02)	< 0.05	1.50 (1.06-2.14)	< 0.05
Daily	23 (78/338)	22 (199/891)	19 (127/652)	1.04 (0.77-1.41)	NS	1.24 (0.90-1.71)	NS
Every other day	21 (72/338)	16 (145/891)	20 (129/652)	1.39 (1.02-1.91)	< 0.05	1.10 (0.79-1.52)	NS
Once a week	22 (74/338)	20 (176/891)	18 (115/652)	1.14 (0.84-1.55)	NS	1.31 (0.94-1.82)	NS
More seldom than once a week	17 (58/338)	20 (177/891)	21 (138/652)	0.84 (0.60-1.16)	NS	0.77 (0.55-1.08)	NS
No complaints	16 (52/332)	21 (187/885)	22 (140/641)	1.44 (1.03-2.02)	< 0.05	1.50 (1.06-2.13)	< 0.05

Table 3 The type of gastrointestinal symptoms among three genotype groups of lactase persistence/nonpersistence

Gastrointestinal symptoms	C/C % (n = 294)	C/T % (n = 725)	T/T % (n = 524)	OR C/C vs C/T(95% CI)	P	OR C/C vs T/T(95% CI)	P
Flatulence	79 (232)	73 (531)	73 (380)	1.37 (0.99-1.89)	< 0.05	1.42 (1.01-1.99)	< 0.05
Diarrhoea	40 (119)	38 (275)	40 (207)	1.11 (0.84-1.47)	NS	1.04 (0.78-1.39)	NS
Constipation	24 (72)	21 (152)	20 (107)	1.22 (0.89-1.68)	NS	1.26 (0.90-1.78)	NS
Bloating	61 (178)	58 (423)	55 (287)	1.10 (0.83-1.44)	NS	1.27 (0.94-1.69)	NS
Heartburn	32 (94)	37 (265)	38 (198)	0.82 (0.61-1.09)	NS	0.77 (0.57-1.04)	NS

Citation: Anthoni SR, Rasinperä HA, Kotamies AJ, Komu HA, Pihlajamäki HK, Kolho KL, Järvelä IE. Molecularly defined adult-type hypolactasia among working age people with reference to milk consumption and gastrointestinal symptoms. World J Gastroenterol 2007; 13(8): 1230-1235
URL: https://www.wjgnet.com/1007-9327/full/v13/i8/1230.htm
DOI: https://dx.doi.org/10.3748/wjg.v13.i8.1230