Colorectal Cancer
Copyright ©2007 Baishideng Publishing Group Co.
World J Gastroenterol. Feb 28, 2007; 13(8): 1187-1194
Published online Feb 28, 2007. doi: 10.3748/wjg.v13.i8.1187
Table 1 Association between p16 and MGMT methylation, K-ras mutations and clinicopathological features of colorectal cancer
Methylation (%)Mutations (%)
Variablep16 (n = 46)MGMT (n = 46)K-ras (n = 84)
Gender
Female9/15 (60.0)7/15 (46.7)15/23 (65.2)a
Male15/31 (48.4)13/31 (41.9)22/61 (36.1)
Dukes’ stage
A5/9 (55.5)5/9 (55.5)8/21 (38.1)
B7/10 (70.0)4/10 (40.0)12/24 (50.0)
C8/15 (53.3)8/15 (53.3)17/39 (43.6)4
D4/12 (33.3)3/12 (25.0)
Differentiation
Poor15/25 (60.0)10/25 (40.0)18/44 (40.9)
Moderate8/18 (44.4)10/18 (55.5)16/26 (61.5)
Well1/3 (33.3)0/3 (0)3/14 (21.4)
Macrosopic type2
Polypoid11/23 (47.8)14/23 (60.7)a25/48 (52.1)
Flat13/23 (56.5)6/23 (26.1)12/35 (34.3)
Histological type2
Mucinous8/19 (42.1)6/19 (31.6)16/34 (47.1)
Tubular16/27 (59.3)14/27 (51.8)21/49 (42.8)
Location2
Proximal3/3 (100)1/3 (33.3)5/9 (55.5)
Distal21/43 (48.8)19/43 (44.2)32/74 (43.2)
Progression (2 yr)1,3
Metastasis or/and death11/25 (44.0)9/25 (36.0)29/44 (65.9)b
Without progression12/19 (63.1)11/19 (57.9)7/37 (18.9)
Table 2 Association between p16 and MGMT methylation, K-ras mutations and immunohistochemical features of colorectal cancer
Methylation (%)Mutations (%)
Variablep16 (n = 46)MGMT (n = 46)K-ras (n = 84)
E-cadherin1,3
Absent13/19 (68.4)9/19 (47.4)28/37 (75.7)b
Heterogeneous4/14 (28.6)7/14 (50.0)4/23 (17.4)
Present6/11 (54.5)4/11 (36.4)4/21 (19.0)
CD44 expression1,3
Absent7/11 (63.6)6/11 (54.5)4/22 (18.2)
Low6/9 (66.7)4/9 (44.4)5/17 (29.4)
Moderate2/7 (28.6)4/7 (57.1)4/10 (40.0)
Extensive8/17 (47.0)6/17 (35.3)23/32 (71.9)b
CD44 type2,4
Membranous9/17 (52.9)7/17 (41.2)9/36 (25.0)
Cytoplasmic13/26 (50.0)12/26 (46.1)27/44 (71.9)b
Laminin1,3
0-25%5/8 (62.5)5/8 (62.5)2/15 (13.3)
25%-75%5/12 (41.7)5/12 (41.7)5/22 (22.7)
> 75%13/24 (54.2)10/24 (41.7)29/44 (65.9)b
PCNAi1,3
01/2 (50.0)2/2 (100)0/2 (0)
0-10%5/9 (55.5)4/9 (44.4)3/17 (17.6)
10%-50%6/9 (66.7)5/9 (55.5)3/20 (15.0)
> 50%11/24 (45.8)9/24 (37.5)30/42 (71.4)b