Serum pepsinogen levels and their influencing factors: A population-based study in 6990 Chinese from North China

Table 1 Serum PG levels in different gender groups (median)

Gender	Cases (n)	PGI (μg/L)	PGII (μg/L)	PGI/II
Male	3455	95.2	12.1	7.9
Female	3535	79.7	9.4	8.3
P value		0.000	0.000	0.000

Table 2 Serum PG levels in different age groups (median)

Age (yr)	Cases (n)	PGI (μg/L)	PGII (μg/L)	PGI/II
A ( ≤ 40)	1813	86.6a	9.9	8.7
B  (41-50)	2225	86.9b	10.6d	8.3f
C (51-60)	1840	88.6c	11.3e	7.8g
D (≥ 61)	1112	84.0	10.9	7.0h

PGI:

^aP = 0.017,

^bP = 0.031,

^cP = 0.019 vs D group; PGII:

^dP = 0.018 vs A group,

^eP = 0.010 vs B group; PGI/II:

^fP = 0.003 vs A group,

^gP = 0.002 vs B group,

^hP = 0.002 vs C group.

Table 3 Serum PG levels in different gastric disease groups (median)

Gastric disease	Cases (n)	PGI (μg/L)	PGII (μg/L)	PGI/II
NOR	494	79.3	7.4	10.4
SG	3654	86.0	9.4	9.0
GEU	362	102.5	14.4	7.5
SG-IM	1347	89.9	12.8	6.8
AG	870	84.8	13.0	6.5
GP	73	87.5	13.3	6.1
GD	110	96.9	15.9	5.7
GC	80	84.4	11.3	6.4

Table 4 Results of Mann-Whitney U test

Group	P value
	PGI	PGII	PGI/II
NOR vs SG	0.000	0.000	0.000
NOR vs GEU	0.000	0.000	0.000
NOR vs AG	0.021	0.000	0.000
NOR vs GC	0.892	0.000	0.000
SG vs GEU	0.000	0.000	0.000
SG vs AG	0.173	0.000	0.000
SG vs GC	0.218	0.060	0.000
GEU vs AG	0.000	0.017	0.002
GEU vs GC	0.000	0.023	0.137
AG vs GC	0.422	0.251	0.809

Table 5 Multivariable logistic regression of the PgI /II ratio

	n	Coeff.	95% CI	P-values
Gender
Female	3535	Baseline
Male	3455	1.151	1.042-1.272	0.006
Age
< 60 yr	5878	Baseline
≥ 61 yr	1112	1.358	1.188-1.553	0.000
Gastric mucosal lesions
Non-atrophy	4510	Baseline
Atrophy	2480	2.075	1.870-2.302	0.000
H pylori
H pylori-	1705	Baseline
H pylori+	5285	1.546	1.368-1.748	0.000