Combination of allopurinol and hyperbaric oxygen therapy: A new treatment in experimental acute necrotizing pancreatitis?

doi:10.3748/wjg.v13.i46.6203

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Dec 14, 2007 (publication date) through Apr 26, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Dec 14, 2007; 13(46): 6203-6207
Published online Dec 14, 2007. doi: 10.3748/wjg.v13.i46.6203

Table 1 Serum amylase levels, oxidative stress parameters, bacterial translocation, histopathologic scores, and mortality rates in the different study groups

	Group I(n = 15)	Group II(n = 12)	Group III(n = 13)	Group IV(n = 13)	Group V(n = 12)
Amylase (U/L)	278 ± 44	1664 ± 234	974 ± 110	384 ± 40	851 ± 56
Oxidative stress
MDA (nmol/g)	12.3 ± 0.4	28.3 ± 0.7	18.2 ± 0.4	16.4 ± 0.4	20.1 ± 0.5
SOD (U/g)	395 ± 7	254 ± 6	345 ± 16	282 ± 8	300 ± 9
GSHPx (U/g)	51.6 ± 2.0	30.8 ± 0.9	35.8 ± 1.5	48.4 ± 0.7	45.6 ± 1.4
Bacterial translocation
MLNs	2 (13%)	12 (100%)	8 (62%)	6 (46%)	7 (58%)
Pancreas	2 (13%)	12 (100%)	7 (54%)	3 (23%)	6 (50%)
Histopathologic score	2 (1-3)	18 (14.5-19)	13 (12.5-15)	6 (4.5-7.5)	9.5(7-11.75)
Mortality	0/15 (0%)	5/17 (29%)	3/16 (19%)	3/16 (19%)	4/16 (25%)

MDA: Malondialdehyde; SOD: Superoxide dismutase; GSHPx: Glutathione peroxidase; MLNs: Mesenteric lymph nodes.

Citation: Comert B, Isik AT, Aydin S, Bozoglu E, Unal B, Deveci S, Mas N, Cinar E, Mas MR. Combination of allopurinol and hyperbaric oxygen therapy: A new treatment in experimental acute necrotizing pancreatitis? World J Gastroenterol 2007; 13(46): 6203-6207
URL: https://www.wjgnet.com/1007-9327/full/v13/i46/6203.htm
DOI: https://dx.doi.org/10.3748/wjg.v13.i46.6203