Protective effect of inducible nitric oxide synthase inhibitor on pancreas transplantation in rats

Table 1 Serum NO level and amylase activity 4 h after transplantation (mean ± SD)

Group	n	NO (μmol/L)	Amylase (U/dL)
Sham-operation group	6	30.0 ± 3.5	342 ± 73
Transplant control group	6	192.3 ± 60.0b	4477 ± 630f
AG-60 mg/kg body weight	6	137.3 ± 21.1	2848 ± 354
AG-80 mg/kg body weight	6	67.9 ± 19.5d	1494 ± 263h
AG-100 mg/kg body weight	6	66.0 ± 16.6	1426 ± 177

^bP < 0.01,

^fP < 0.01 vs sham-operation group;

^dP < 0.01,

^hP < 0.01 vs transplant control group.

Table 2 Blood sugar level 4 h after transplantation (mean ± SD)

Group	n	Pretransplantation (mmol/L)	Posttransplantation (mmol/L)
Sham-operated control	6	19.6 ± 1.4a	-
Transplant control group	6	20.1 ± 2.0a	16.9 ± 2.0
AG-60 mg/kg body weight	6	19.9 ± 1.5a	16.8 ± 1.1
AG-80 mg/kg body weight	6	19.8 ± 1.7a	14.2 ± 0.9b
AG-100 mg/kg body weight	6	20.5 ± 1.6a	15.1 ± 1.8c

^aP > 0.05,

^bP < 0.01 vs AG-60 mg/kg body weight post transplantation;

^cP > 0.05 vs AG-80 mg/kg body weight post transplantation.

Table 3 Activity of NOS isoforms in pancreatic tissue 4 h after transplantation (mean ± SD)

Group	n	cNOS (U/mL)	iNOS (U/mL)
Sham-operation group	6	5.35 ± 1.01a	1.87 ± 0.19
Transplant control group	6	5.91 ± 0.71a	26.59 ± 5.78b
(AG-80 mg/kg body weight)	6	5.64 ± 0.97a	2.01 ± 0.23d

^aP > 0.05,

^bP < 0.01 vs sham-operation group;

^dP < 0.01 vs transplant control group.