Novel genetic markers in inflammatory bowel disease

Table 1 Major regions and genes in IBD

Region	Localization	Involved genes
IBD1	Chromosome 16	NOD2/CARD15, IL-4R, CD11B
IBD2	Chromosome 12	Vitamin D receptor (VDR), STAT6, Interferon γ, β7 integrine.
IBD3	Chromosome 6	Major histocompatibility complex (MHC): Class I,II, III.
IBD4	Chromosome 14	T- Lymphocyte receptor (TCR) and Leukotriene B4
IBD5	Chromosome 5	Organic cations transporter (OCTN), Drosophila long disc homologue gene 5 (DLG5), Multidrug resistant gene (MDR1), IL-6, CD14
IBD6	Chromosome 19	Thromboxane A2, Leukotriene B4, ICAM-1
IBD7	Chromosome 1	Transforming growth factor Beta (TGFβ), TNFα receptors.
IBD8	Chromosome 16	Under research
IBD9	Chromosome 9	CCR-5, CCR9, IL-12

NOD2/CARD15: Nucleotide oligomerization domain 2/Caspase-activation recruitment domains 15; STAT6: signal transducer and activator of transcription-6; ICAM-1: intracellular adhesion molecule 1; CCR5: CC-chemokine receptor5.