Achalasia and thyroid disease

Table 1 Test and methods used in this study

Test title	Kit	Manufacturedcountry
Anti nuclear anti body (ANA)	Biostems	Spain
Antineutrophil cytoplasm antibody (c-ANCA)	Binding site	England
Calcium	Man	Iran
Phosphorus	Man	Iran
Alkaline phosphatase	Man	Iran
Thyroid stimulating hormone(TSH)	Isfahan pharmacology faculty	Iran
T3 Resin uptake	kavoshiar	Iran
T3, T4	Isfahan pharmacology faculty	Iran
Albumin	Man	Iran
Globulin	Man	Iran
Rapid plasmin reagin (RPR)	Anison	Iran
Urine analysis	Combi	Germany
Complete blood count	-	Germany

All tests except for urine analysis were performed on blood or serum samples.

Table 2 Average score of all patients and those suffering from thyroid disease respectively (mean ± SD)

	Patients withhypothyroidism	Patients with benignthyroid diseases1	Patients withoutthyroid problems	Mean score ofall patients
Age	39.5 ± 14.3 a	35.8b± 11.9b	38.5 ± 18.1	37.9 ± 16.7
Dysphagia	5c	4.5 ± 1.1d	4.8 ± 0.45	4.8 ± 0.66
Regurgitation	5e	4.7 ± 0.75f	3.5 ± 1.9	3.8 ± 1.8
Nocturnal cough	2.5 ± 2.8 g	2.5 ± 2.5h	2.5 ± 2.2	2.5 ± 2.2
Chest discomfort	3.75 ± 1.5 i	2.2 ± 2.1 j	1.86 ± 2.7	1.96 ± 2
Weight loss	0.5 ± 0.5k	0.4 ± 0.5l	0.65 ± 4.08	0.6 ± 0.49

Scoring system: 0 = none; 1 = once per month or less; 2 = three to four times a month; 3 = two to four times per week; 4 = once per day; 5 = several times per day,

¹Composed of thyroid nodules, hypothyroidism and hyperthyroidism. No significant differences between groups were found by independent t-test, Mann-Witney test and chi-square test. P values of differences between thyroid disease groups and other patients with achalasia: ^a: 0.7;

^b: 0.7;

^c: 0.5;

^d: 0.6;

^e: 0.09;

^f: 0.1; ^g: 1;

^h: 0.97; ^I: 0.08;

^j: 0.57;

^k: 0.6;

^l: 0.3. (the first and second columns were compared with the third column).

Table 3 Overall and specific ethnicity and gender of all patients and those suffering from thyroid disease respectively

	Hypothyroid patients		Benign thyroid diseases1		Without thyroid problems		Total
	n	%	n	%	n	%	n	%
Number	4	13.3	7	23.7	23	76.6	30	100
Gender	♂1 ♀3	♂25 ♀75	♂2 ♀5	♂28 ♀72	♂8 ♀15	♂34 ♀66	♂10 ♀20	♂33 ♀67
Ethnicity2	F: 3	F: 75	F: 5	F: 71	F: 16	F: 69	F: 21	F: 70
	B: 1	B: 25	B: 2	B: 28	B: 5	B: 21	B: 7	B: 23

¹Composed of thyroid nodules, hypothyroidism and hyperthyroidism.

²Composed of the most common ethnicity in patients, F: Fars; B: Bakhtiari.

Table 4 Final result of laboratory evaluation in all patients

Test	Normal (%)	Abnormal (%)
Thyroid function tests	80	20
Calcium and phosphorus	100	-
Alkaline phosphatase	100	-
Albumin	100	-
Globulin	100	-
ANA	93.4	6.6
C_ANCA	100	-
RPR (VDRL)	100	-
Complete Blood Count	100	-
Urine analysis	100	-

All tests except for urine analysis were performed on blood or serum samples.