Topic Highlight
Copyright ©2007 Baishideng Publishing Group Co.
World J Gastroenterol. Sep 28, 2007; 13(36): 4858-4864
Published online Sep 28, 2007. doi: 10.3748/wjg.v13.i36.4858
Table 1 Regulatory T cell subsets in HCV and HBV infection
Regulatory T cell phenotypeVirusCompartmentSuppressionCytokines
CD4+CD25+ (FoxP3+)[42-46,48,54,56,58,61,62]HCV HBVBlood/LiverCell-cell contact dependent suppression of antigen specific and unspecific T cell proliferation and cytokine productionIn part IL-10/ TGF-β
CD4+ (TR1 cells)[49]HCVBloodIL-10
CD8+ (FoxP3+)[50-52]HCV HCVBlood/Liver BloodSuppression of antigen specific T cell proliferation and INF-γ secretion Cell-cell contact suppression of antigen unspecific T cell proliferationIL-10/TGF-β IFN-y