Regulatory T cells in viral hepatitis

Table 1 Regulatory T cell subsets in HCV and HBV infection

Regulatory T cell phenotype	Virus	Compartment	Suppression	Cytokines
CD4+CD25+ (FoxP3+)[42-46,48,54,56,58,61,62]	HCV HBV	Blood/Liver	Cell-cell contact dependent suppression of antigen specific and unspecific T cell proliferation and cytokine production	In part IL-10/ TGF-β
CD4+ (TR1 cells)[49]	HCV	Blood		IL-10
CD8+ (FoxP3+)[50-52]	HCV HCV	Blood/Liver Blood	Suppression of antigen specific T cell proliferation and INF-γ secretion Cell-cell contact suppression of antigen unspecific T cell proliferation	IL-10/TGF-β IFN-y
CD8+FoxP3+
CTLA-4+GITR+[53]