Liver Cancer
Copyright ©2007 Baishideng Publishing Group Co.
World J Gastroenterol. Aug 21, 2007; 13(31): 4192-4198
Published online Aug 21, 2007. doi: 10.3748/wjg.v13.i31.4192
Table 1 Effect of Huqi San on the number and size of DEN-induced γ-GT positive foci in rat liver (mean ± SD)
Experimental groupsnNumber of γ-GTfoci (per cm2)Area of γ-GTfoci (mm2/cm2)
Normal group100.23 ± 0.09a0.18 ± 0.08a
PH group120.31 ± 0.08a0.21 ± 0.10a
Prevention group124.96 ± 0.72a5.12 ± 3.62a
Large dose therapeutic group (8 g/kg body weight)127.53 ± 0.88a8.76 ± 3.97a
Small dose therapeutic group (4 g/kg body weight)1212.77 ± 0.93b13.63 ± 3.44b
Model group1229.46 ± 2.1721.1 ± 2.98
Table 2 Effect of Huqi San on c-jun, c-fos and c-myc protein level in liver (mean ± SD, mm2)
c-jun protein
c-fos protein
c-myc protein
Experimental groupsLevelFold of controlLevelFold of controlLevelFold of control
Normal group0.28 ± 0.03a-0.29 ± 0.04a-0.12 ± 0.02a-
PH group0.24 ± 0.02a0.860.29 ± 0.03a1.000.17 ± 0.01a1.41
Prevention group0.41 ± 0.01a1.460.33 ± 0.09a1.140.36 ± 0.07a3.00
Large dose herapeutic group (8 g/kg body weight )0.58 ± 0.02b2.070.56 ± 0.02b1.930.48 ± 0.01a4.00
Small dose therapeutic group (4 g/kg body weight )0.71 ± 0.06b2.540.77 ± 0.08a2.660.69 ± 0.06b5.75
Model group0.89 ± 0.033.180.91 ± 0.073.140.99 ± 0.048.25