Basic Research
Copyright ©2007 Baishideng Publishing Group Co.
World J Gastroenterol. Jan 21, 2007; 13(3): 378-382
Published online Jan 21, 2007. doi: 10.3748/wjg.v13.i3.378
Table 1 Grading of pancreatic fibrosis
GradeDuctdilationPeriductalfibrosisIntralobularfibrosisGlandularatrophy
F0----
F1+---
F2++--
F3+++-
F4++++
Table 2 Effect of emodin on serum hyaluronic acid (HA) and laminin (LN) (mean ± SE)
GroupnHA (μg/L)LN (μg/L)
1 (Normal)1055.2 ± 23.740.5 ± 12.2
2 (Control)8112.7 ± 26.5b86.2 ± 16.5b
3 (emodin, 20 mg/kg)886.6 ± 22.1a66.8 ± 14.4a
4 (emodin, 40 mg/kg)878.0 ± 24.5d56.7 ± 12.3a
5 (emodin, 80 mg/kg)962.2 ± 19.3d44.3 ± 10.4d
Table 3 Pancreatic collagen content in different groups (mean ± SE, %)
GroupnPositive proportion
2 (Control)842 ± 6
3 (emodin, 20 mg/kg)839 ± 7
4 (emodin, 40 mg/kg)838 ± 4
5 (emodin, 80 mg/kg)936 ± 5a
Table 4 Immunochemistry results in different groups (percentage of TGF-β1 positive cells)
Groupn0++2+3+4
1 (Normal)1091000
2 (Control)800044
3 (emodin, 20 mg/kg)800440
4 (emodin, 40 mg/kg)804310
5 (emodin, 80 mg/kg)945000