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©2007 Baishideng Publishing Group Co.
World J Gastroenterol. Jul 28, 2007; 13(28): 3784-3791
Published online Jul 28, 2007. doi: 10.3748/wjg.v13.i28.3784
Published online Jul 28, 2007. doi: 10.3748/wjg.v13.i28.3784
Table 1 Characteristics of different CRC pathways
| Predominantpathway | MSI/CIMPstatus | Site ofcancer | Prognosis | CIN | GermlineMMR mutation | Somatic BRAFmutation | MLH1methylation | MGMTmethylation | Immediateprecursor |
| Mutator | MSI-H/CIMP- | Proximal | Better | No | Yes | No | No | No | Advanced adenoma |
| Methylator/Mutator | MSI-H/CIMP+ | Proximal | Better | No | No | Yes | Yes | No | Serrated polyp |
| Methylator | Non-MSI-H/CIMP+ | Proximal | Worse | No | No | Yes | No | No | Serrated polyp |
| “Alternate” methylator | MSI-L/CIMP+ | Distal | Unclear | No | No | No (K-ras) | No | Yes | Serrated polyp |
| Suppressor | Non-MSI-H/CIMP- | Distal | Standard | Yes | No | No | No | No | Advanced adenoma |
- Citation: Worthley DL, Whitehall VL, Spring KJ, Leggett BA. Colorectal carcinogenesis: Road maps to cancer. World J Gastroenterol 2007; 13(28): 3784-3791
- URL: https://www.wjgnet.com/1007-9327/full/v13/i28/3784.htm
- DOI: https://dx.doi.org/10.3748/wjg.v13.i28.3784