Effects of four Indian medicinal herbs on Isoniazid-, Rifampicin- and Pyrazinamide-induced hepatic injury and immunosuppression in guinea pigs

Table 1 Effects of AKT, Herb and Herb + AKT on Liver enzymes (mean ± SE, n = 4)

Treatment	AST	ALT	AST/ALT	ALP
CT	47 ± 6.15	55 ± 7.86	0.92 ± 0.03	68.75 ± 2.69
AKT	239.5 ± 7.77d	61.75 ± 1.97	3.82 ± 0.23d	125 ± 5.23d
CL	56.75 ± 4.77	51.25 ± 3.57	1.11 ± 0.09	54 ± 1.47b
CL+AKT	95.75 ± 7.69h	48 ± 8.26	2.13 ± 0.28f	62 ± 6.28h
OS	47 ± 2.16	57 ± 4.55	0.83 ± 0.04	61.5 ± 2.63
OS+AKT	128.75 ± 10.87h	64.5 ± 10.48	2.12 ± 0.31f	54.25 ± 2.17h
TC	44.5 ± 4.29	49.5 ± 5.20	0.9 ± 0.03	66.25 ± 2.95
TC+AKT	104 ± 6.79h	62.75 ± 9.24	1.77 ± 0.31f	60.75 ± 3.9h
ZM	43.75 ± 0.75	51.25 ± 2.02	0.85 ± 0.02	59.25 ± 1.55
ZM+AKT	132.5 ± 25.88h	62.75 ± 8.98	2.1 ± 0.35f	61.25 ± 1.77h

^bP≤ 0.01, CT vs CL;

^dP≤ 0.001, CT vs AKT;

^fP≤ 0.01,

^hP≤ 0.001, AKT vs CL + AKT, OS + AKT, TC + AKT and ZM + AKT. No significant effect of any herb on liver enzymes.

Table 2 Effects of AKT, Herb and Herb + AKT on PMN function (mean ± SE, n = 4)

Treatment	P%	P. Index	C. Index
CT	51.67 ± 1.68	2.0725 ± 0.05	1.8525 ± 0.04
AKT	40.61 ± 1.28b	0.61 ± 0.05d	0.695 ± 0.07d
CL	73.3475 ± 0.75d	2.47 ± 0.14	1.83 ± 0.03
CL + AKT	72.725 ± 1.14f	2.3425 ± 0.17f	1.22 ± 0.03f
OS	58.3875 ± 1.42b	2.46 ± 0.15	1.7975 ± 0.04
OS + AKT	55.1325 ± 0.89f	1.1875 ± 0.05a	1.5425 ± 0.04f
TC	70.9925 ± 0.99d	4.4 ± 0.09d	1.8775 ± 0.02
TC + AKT	70.9875 ± 0.97f	4.4625 ± 0.16f	1.8675 ± 0.04f
ZM	76.7675 ± 0.48d	2.3925 ± 0.07	2.0425 ± 0.03b
ZM +AKT	75.1 ± 0.7f	2.34 ± 0.10f	2.0575 ± 0.05f

^bP≤ 0.01;

^dP≤ 0.001, CT vs AKT, CL, OS, TC and ZM;

^aP≤ 0.05,

^fP≤ 0.001, AKT vs CL + AKT, OS + AKT, TC + AKT and ZM + AKT.