Useful detection of CD147 (EMMPRIN) for pathological diagnosis of early hepatocellular carcinoma in needle biopsy samples

Table 1 Characteristics of patients undergoing tumor biopsies (n = 22)

Features	Median value
Age	68 (56-81)
Sex (Male/Female)	15/7
Plt (× 103/μL)	10.0 (5.1-24.5)
AST (IU/L)	68 (21-147)
ALT (IU/L)	61.5 (6-214)
T-Bil (mg/dL)	0.8 (0.4-2.3)
γ-GTP (IU/L)	48 (18-665)
AFP (ng/mL)	21.5 (3-444)
HBs Ag/HCV Ab/Others	3/18/1
Tumor size (mm)	14.5 (8-23)
Cirrhosis (positive/negative)	5/17
Differentiation (well/moderate)	15/7

Data values are expressed as the medians with ranges in parentheses unless indicated otherwise. Normal ranges: Plt (platelet count), 15-35 × 10³/L; AST (aspartate aminotransferase), 10-33 IU/L; ALT (alanine aminotransferase), 6-35 IU/L; T-Bil (total bilirubin), 0.2-1.2 mg/dL; γ-GTP (γ-glutamyl transferase), 10-50 IU/L; AFP (α-fetoprotein), > 20 ng/mL.

Table 2 Immunohistochemical scales of tumor and non-tumor biopsy specimens

4-step scales	Tumor tissues	Non-tumor tissues	P
	n (%)	n (%)
Very weak (0)	1 (4.5)	7 (31.8)	< 0.01
Weak (1)	6 (27.3)	6 (27.3)
Moderate (2)	3 (13.6)	6 (27.3)
Strong (3)	12 (54.5)	3 (13.6)
Total	22 (100)	22 (100)