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©2007 Baishideng Publishing Group Co.
World J Gastroenterol. Apr 21, 2007; 13(15): 2187-2192
Published online Apr 21, 2007. doi: 10.3748/wjg.v13.i15.2187
Published online Apr 21, 2007. doi: 10.3748/wjg.v13.i15.2187
Table 1 Demographic profile of patients with chronic HCV infection
| Patients | n = 284 | |
| Gender M/F | 166/118 | |
| mean ± SD | Range | |
| Age (yr) | 42.6 ± 11.3 | 21-75 |
| Age of Infection (yr) | 24.3 ± 11.4 | 1-57 |
| Age of liver biopsy (yr) | 40.1 ± 11.8 | 16-70 |
| ALT IU/L | 121.3 ± 100.9 | 16-660 |
| AST IU/L | 67.6 ± 44.3 | 16-300 |
| GGT IU/L | 53.9 ± 53.8 | 10-472 |
| AP IU/L | 181.35 ± 65.6 | 73-637 |
| Viral load (106) copies /mL | 1.29 ± 1.3 | 0.0015-6.3 |
| Viral genotypes | n = 205 (%) | |
| I | 159 (77.6) | |
| II | 7 (3.4) | |
| III | 27 (13.2) | |
| IV | 5 (2.4) | |
| I + another | 7 (3.4) |
Table 2 Genotypic and allelic distribution of the –2518 CCL2 (A/G) and CCR2 polymorphisms in Spanish patients with chronic hepatitis C (CHC) and healthy controls
| Genotypes | CHCn = 284 (%) | F0-F2n = 202 (%) | F3-F4n = 82 (%) | SRn = 101 (%) | NSRn = 98 (%) | Healthy controlsn = 193 (%) |
| -2518 CCL2 AA | 168 (59.2) | 123 (60.9) | 45 (54.0) | 64 (63.4) | 55 (56.1) | 119 (61.6) |
| -2518 CCL2 AG + GG | 116 (40.9) | 79 (39.1) | 37 (46.0) | 37 (36.6) | 43 (43.9) | 74 (38.4) |
| 190 CCR2 GG | 205 (72.2) | 146 (72.3) | 59 (72.0) | 72 (71.3) | 74 (75.5) | 156 (80.8%) |
| 190 CCR2 AG + AA | 79 (27.8) | 56 (27.7) | 23 (28.0) | 29 (28.7) | 24 (24.5) | 37 (19.1%) |
| CCR2 rs3138042 AA | 134 (47.2) | 93 (46.0) | 41 (50.0) | 48 (47.5) | 46 (46.9) | 102 (52.9) |
| CCR2 rs3138042 AG | 124 (43.7) | 91 (45.1) | 33 (40.2) | 42 (41.6) | 45 (45.9) | 72 (37.3) |
| CCR2 rs3138042 GG | 26 (9.2) | 18 (8.9) | 8 (9.8) | 11 (10.9) | 7 (6.9) | 19 (9.8) |
Table 3 Interactions between -2518 CCL2 G and 190 CCR2 A mutations
| Chronic hepatitis | F0-F2 | F3-F4 | SR | NSR | Healthy controls | ||
| n = 284 (%) | n = 202 (%) | n = 82 (%) | n =101 (%) | n =98 (%) | n = 193 (%) | ||
| CCL2G | CCR2A | 31 (10.9) | 22 (10.9) | 9 (11.0) | 10 (9.9) | 11 (11.2) | 13 (6.7) |
| CCL2G | CCR2G | 85 (29.9) | 57 (28.2) | 28 (34.1) | 27 (26.7) | 32 (32.6) | 61 (31.6) |
| CCL2A | CCR2A | 48 (16.9) | 34 (16.8) | 14 (17.1) | 19 (18.8) | 13 (13.3) | 24 (12.4) |
| CCL2A | CCR2G | 120 (42.2) | 89 (44.1) | 31 (37.8) | 45 (44.5) | 42 (42.8) | 95 (49.2) |
- Citation: Montes-Cano M, García-Lozano J, Aguilar-Reina J, Romero-Gómez M, Barroso N, Núñez-Roldán A, González-Escribano M. CCL2-2518 A/G and CCR2 190 A/G do not influence the outcome of hepatitis C virus infection in the Spanish population. World J Gastroenterol 2007; 13(15): 2187-2192
- URL: https://www.wjgnet.com/1007-9327/full/v13/i15/2187.htm
- DOI: https://dx.doi.org/10.3748/wjg.v13.i15.2187