Topic Hightlights
Copyright ©2007 Baishideng Publishing Group Co.
World J Gastroenterol. Apr 14, 2007; 13(14): 2037-2043
Published online Apr 14, 2007. doi: 10.3748/wjg.v13.i14.2037
Table 1 Major drug transporters possibly involved in the drug resistance of HCC
TransporterDrugs interested
P-glycoprotein (MDR1, ABCB1)Anthracyclines, Mitoxantrone, Podophyllotoxin derivatives, Taxanes, Vinca alkaloids
MRP2 (ABCC2, cMOAT)Anthracyclines, Cisplatin, Methotrexate, Irinotecan metabolites, Vinca alkaloids
MRP3 (ABCC3)Etoposide, Methotrexate
LRP (Major vault protein, MVP)Cisplatin, Doxorubicin, Etoposide, 5-fluorouracil, Paclitaxel, Vincristine
TAP (Transporter associated with antigen processing)Doxorubicin, Etoposide, Mitoxantrone, Vincristine