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Copyright ©2007 Baishideng Publishing Group Co.
World J Gastroenterol. Jan 7, 2007; 13(1): 82-90
Published online Jan 7, 2007. doi: 10.3748/wjg.v13.i1.82
Table 1 HBV variants and their potential impact for pathogenesis of HBV infection
HBV regionMutationMolecular phenotypeClinical relevance
Pre-S/SPre-S1/ pre-S2/MisassemblyFibrosing cholestatic
SAlteration of B- andVaccine escape
S splicingT-cell epitopesImmune escape Diagnostic escape
Pre-CPre-C-stopLoss of HBeAgSevere hepatitis HBeAg-deficiency
CoreCoreAlteration of T-cell epitopesViral persistence Severe hepatitis
RT/PolPolReplication deficiencyViral latency Viral latency Pol
Resistance to antiviralsTherapy escape
Regulatory Core promotor ElementsEnhanced replication and core expression Decreased HBeAg synthesisSevere hepatitis Modulation of drug resistance HBeAg seronegativity
Enhancer IDecreased replicationChronic hepatitis