Does endothelium agree with the concept of idiopathic hepatic vessel thrombosis

Table 1 Applied exclusion criteria

Exclusion criteria
Acute thrombosis of portal or hepatic veins
Any ultrasonographic (including Doppler studies) finding compatible with mass occupying lesion in liver
Positivity of viral hepatitis markers
Any finding in the liver biopsy suggesting parenchymal liver disease (including autoimmune liver diseases and metabolic liver diseases)
Acquired hematological abnormality leading to thrombophilia (myeloproliferative diseases, paroxysmal nocturnal hemoglobinuria, history of use of oral contraceptive or estrogen replacement treatment, anti-phospholipid syndrome, history of cancer, history of hepatobiliary surgery, history of pancreatitis)
Genetic hematological abnormality leading to thrombophilia (mutation of factor V Leiden, mutation of prothrombin, deficiencies in proteins C and S or antithrombin, hyperfibrinogenemia, hyperhomocysteinemia)
Severe and widespread atherosclerosis, uncontrolled or newly diagnosed malignancy elsewhere, systemic inflammatory diseases, history of recent operation

Table 2 General characteristics of the patients (results were given as minimum, maximum and median)

Test	Result
Age	28-74 (48)
Female/Male	6/3
PVT (n)	7
HVT (n)	2
Hemoglobin (gr/L)	9.5-16.6 (13.5)
Platelet (count/mL)	62.000-358.000 (168.000)
ALT (U/L)	13-38 (23)
AST (U/L)	18-38 (27)
ALP (U/L)	87-355 (200)
GGT (U/L)	16-123 (34)
Total Bilirubin (mg/L)	0.24-2.08 (0.65)
INR	1.06-1.47 (1.14)
Protein C (%)	55-137 (87)
Protein S (%)	58-113 (85)
AT (%)	75-109 (90)
Homocysteine (umol/L)	9-19 (15)
Fibrinogen (mg/L)	181-420 (271)

Table 3 Comparison of patient and control groups by advanced tests (results were given as minimum, maximum and median)

Test (normal limits)	Patient group (n)	Control group (n)	Significance
FVIIa (25.5-96.9 mU/mL)	27-1232 (96)	39-325 (129)	NS1
Total TFPI (81.2 ± 30.4 ng/mL)	22-114 (87.2)	43-112 (79)	NS
Free TFPI (10.0 ± 4.8 ng/mL)	5-41 (19)	9-20 (13)	aP < 0.05
sVCAM (395-714 ng/mL)	489-1890 (915)	410-890 (517)	cP < 0.05
sICAM (115-306 ng/mL)	148-400 (252)	24-260 (164)	bP < 0.05
E-Selectin (29.1-63.4 ng/mL)	14-68 (20)	11-64 (29)	NS

¹NS: Not significant;

^aP < 0.05,

^cP < 0.05,

^bP < 0.05 vs control group.

Table 4 Results and comparisons of GFC (global fibrinolytic capacity)

Group	Severely low GFC	Moderately low GFC	Normal GFC
Patient group	0	4	5
Control group	0	0	14
	Fisher’s exact test		P < 0.05