Colorectal Cancer
Copyright ©2006 Baishideng Publishing Group Co.
World J Gastroenterol. Feb 28, 2006; 12(8): 1192-1197
Published online Feb 28, 2006. doi: 10.3748/wjg.v12.i8.1192
Table 1 Details of the pedigree analysis
ClassificationDegree of relationship7 exonmutation3 exonmutationType of the tumor,age at tumor detectionAge at investigation
I/1Sister of the mother of the index person’s motherBreast cancer, 61 yrDied
I/2Mother of the index person’s mother76 yr
I/3Brother of the father of the index person’s mother+CRC, 56 yr68 yr
I/4Sister of the father of the index person’s mother+61 yr
I/5Husband of the person No I/4+64 yr
I/6Mother of the index person’s fatherGastric cancer, 55 yrDied
I/7Father of the index person’s fatherLung cancer, 75 yrDied
II/1Index person’s mother+CRC, 43 yr54 yr
II/2Index person’s father+58 yr
II/3Sister of index person’s father+48 yr
II/4The middle son of person No I/4++CRC, 34 yr36 yr
II/5The youngest son of person No I/4+32 yr
II/6The oldest son of person No I/439 yr
III/1Index person++CRC, 31 yr33 yr
III/2Index person’s younger brother++28 yr
IV/1Older son of the index person3 yr
IV/2Younger son of the index person1 yr
Table 2 Type and location of detected mutations
GeneExonCodonMutationType
hMSH27422gaa→taa Glu→STOPNonsense
hMSH23127aat→agt Asn→SerMissense