Effect of oral naltrexone on pruritus in cholestatic patients

Table 1 Characteristics of patients before therapy (n=34)

Characteristics	Range	Mean ± SD
Age (yr)	32-72	53.97 ± 11.93
ALP	190-1150	657.76 ± 266.36
Total bilirubin	5.8-37.00	16.60 ± 9.03
Direct bilirubin	4-32.5	13.14 ± 8.05
ALT	32-145	66.03 ± 27.13
AST	35-110	60.47 ± 19.73
Creat.	0.7-1.3	1.01 ± 0.14
Pruritus in day before therapy	6-10	8.30 ± 1.07
Pruritus in night before therapy	8-10	9.13 ± 0.78

Table 2 Comparison of pruritus scores in patients before and after placebo and naltrexone therapy (mean±SD)

Patients	1	2	3	1 and 2	1 and 3	2 and 3
(n = 34)	Before therapy	After placebo	After therapy	Significance	Significance	Significance
Pruritus in day	8.30 ± 1.07	7.54 ± 1.38	4.91 ± 2.56	P < 0.001	P < 0.001	P < 0.001
Pruritus in night	9.13 ± 0.78	8.29 ± 1.02	5.54 ± 2.51	P  < 0.001	P < 0.001	P < 0.001