Fraser JS, King AL, Ellis HJ, Moodie SJ, Bjarnason I, Swift J, Ciclitira PJ. An algorithm for family screening for coeliac disease. World J Gastroenterol 2006; 12(48): 7805-7809 [PMID: 17203524 DOI: 10.3748/wjg.v12.i48.7805]
Corresponding Author of This Article
Professor P J Ciclitira, Department of Gastroenterology, The Rayne Institute (KCL), St Thomas’ Hospital, London SE1 7EH, United Kingdom. paul.ciclitira@kcl.ac.uk
Article-Type of This Article
Rapid Communication
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World J Gastroenterol. Dec 28, 2006; 12(48): 7805-7809 Published online Dec 28, 2006. doi: 10.3748/wjg.v12.i48.7805
Table 1 Sensitivity, specificity and reproducibility of screening coeliac serology
IgA-AGA
IgG-AGA
IgA-EMA
Sensitivity
83
86
90
Specificity
82
76
99
Table 2 Overall results of coeliac screening for singly and multiply affected families
Type of family
Coeliacs
Relatives
Positive
1st degree
2nd degree
Not
(n)
(n)
screenings
relatives
relatives
related
Singly affected family
73
223
11
11
0
0
Multiply affected family
232
691
28
22
2
4
Table 3 Single affected families-relationships of individuals to probands
Relationship
Numbertested (n)
Numberaffected (n)
Percentageaffected (%)
Mother
73
5
6.85
Father
73
4
5.48
Sibling
37
2
5.41
Child
18
0
0
Uncle/Aunt
5
0
0
Grandparent
6
0
0
Grandchild
2
0
0
Nephew/Niece
3
0
0
Husband/Wife
6
0
0
Table 4 Mutliply affected Families-Relationships of Individuals to probands
Relationship
Numbertested (n)
Numberaffected (n)
Percentageaffected (%)
Mother
51
3
5.88
Father
31
3
9.68
Sibling
165
9
5.4
Child
137
7
5.11
Uncle/Aunt
6
1
16.67
Grandparent
11
0
0
Grandchild
39
0
0
Nephew/Niece
67
1
1.49
3rd degree or more
24
0
0
Husband/Wife
159
4
2.52
Table 5 Results of HLA-typing for individuals with positive screening tests
HLA-type
DR3/DRx
DR3/DR7
DR5/DR7
DR4
DR3/DR4
DR4/DR7
Number
25
4
0
0
0
0
Percentage
86.2%
13.8%
0
0
0
0
Citation: Fraser JS, King AL, Ellis HJ, Moodie SJ, Bjarnason I, Swift J, Ciclitira PJ. An algorithm for family screening for coeliac disease. World J Gastroenterol 2006; 12(48): 7805-7809